Search for dissertations about: "Microglial activation"

Showing result 21 - 25 of 60 swedish dissertations containing the words Microglial activation.

  2. 21. The role of myeloid cells in neurodegenerative diseases. Studies on cellular phenotype and communication

    Author : Yiyi Yang; Neuroinflammation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microglia; Neuroinflammation; Alzherimer’s disease; Stroke; Innate immune system; Systemic inflammation; Monocytes; Single-cell sequencing;

    Abstract : Neurological disorders are listed as the second leading cause of death worldwide. Stroke and Alzheimer’s disease (AD) are the major contributors to neurological disorders of deaths. Every year, around 14 million new people are affected by stoke and nearly 10 million new cases of AD are diagonosed worldwide. READ MORE

  4. 22. Resolution of inflammation as a therapeutic target for Alzheimer’s disease

    Author : Mingqin Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, clinically manifested by memory impairment, loss of ability in conducting daily activity and increased need for care, thus causing immense suffering for the afflicted and relatives, as well as a huge economic burden to the society. Despite the existence of symptom-relieving drugs, there is no drug that can stop the progression or cure the disease. READ MORE

  5. 23. Astroglial Cells : Role in Neurodegenerative-Inflammatory Processes in the Central Nervous System

    Author : Gun Eriksson; Karl Åkerman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Abstract : Inflammatory processes, mediated by the pro-inflammatory cytokines interleukin (IL) -1a/b, tumor necrosis factora(TNFa), IL-6 and excitotoxic actions of glutamate, are proposed to be implicated in neurodegenerative diseases, such as Alzheimer's disease.A neurotoxic fragment ofb-amyloid,bA25-35, was shown to induce a reactive phenotype of primary astrocytes and microglial cells in a time-dependent manner. READ MORE

  6. 24. Deciphering and fine-tuning of myeloid cells in CNS demyelinating conditions

    Author : Keying Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Demyelination in the central nervous system (CNS) is a characteristic of various neurological disorders, such as multiple sclerosis (MS), neuromyelitis optica (NMO), subacute combined degeneration (SCD), tabes dorsalis (syphilitic myelopathy), and more. Although the causes vary, CNS demyelination is often associated with a significant buildup of inflammatory activated myeloid cells, mainly consisting of CNS resident microglia and infiltrating monocyte-derived macrophages. READ MORE

  7. 25. Role of cytokines in experimental neurodegenerative and neuroinflammatory disorders

    Author : Xing-Mei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Altered expression of cytokines in response to body injury has diverse actions that can exacerbate, mediate, reduce or inhibit neuronal and myelin damage as well as influence the disease development in a variety of nervous system disorders, such as Alzheimer s disease (AD), multiple sclerosis and Guillain-Barré Syndrome (GBS). In these studies, we attempted to explore the possible roles of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in experimental neurodegenerative and neuroinflammatory disorders. READ MORE