Search for dissertations about: "Microglial activation"

Showing result 31 - 35 of 60 swedish dissertations containing the words Microglial activation.

  2. 31. The use of adipose derived stem cells in spinal cord and peripheral nerve repair

    Author : Mallappa K Kolar; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; adipose derived stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Abstract : Clinically, injuries affecting the spinal cord or peripheral nerves can leave those affected with severe disability and, at present, there are limited options for treatment. Peripheral nerve injury with a significant gap between the proximal and distal stumps is currently treated with autologous nerve grafting but this is limited by availability of donor nerve and has associated morbidities. READ MORE

  4. 32. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

    Author : Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Abstract : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. READ MORE

  5. 33. Inflammatory proteins in the CNS-relation to Alzheimer's disease

    Author : Catharina Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Most neurodegenerative disorders are characterised by an inflammatory process in the brain. Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the elderly. Activated astrocytes and microglia surrounding the amyloid plaques represent evidence for neuroinflammation in the AD brain. READ MORE

  6. 34. On optic nerve injury : experimental studies on axonal regeneration in the adult mammalian CNS

    Author : Marcus Ohlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Astroglia; axon; degeneration; glial scar; immunohistochemistry; macrophage; methylprednisolone; microglia; neurosurgery; optic nerve; rat; regeneration and visual evoked potentials;

    Abstract : Optic nerve injury may occur after a trauma to the head and in many cases it causes partial or total blindness. Today, these patients cannot be offered any specific treatment to restore visual function. READ MORE

  7. 35. Pain in rheumatoid arthritis : bone and neuroinflammation-associated mechanisms

    Author : Resti Rudjito; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pain is often the primary reason patients with rheumatoid arthritis (RA) seek medical care. Despite effective disease control with currently available disease modifying antirheumatic drugs (DMARDs), there are still hurdles to overcome as a significant proportion of patients still report continuous pain. READ MORE