Search for dissertations about: "Microglial activation"

Showing result 36 - 40 of 60 swedish dissertations containing the words Microglial activation.

  2. 36. Neuroinflammation and its resolution in Alzheimer's disease

    Author : Ying Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is the most common dementia with high prevalence among an increasing aged population. Despite the existence of symptom-reliving drugs for AD, the clinical trials performed until now have failed to find drugs that cure or stop the progression of AD. New perspectives and strategies for treatments are therefore direly needed. READ MORE

  4. 37. Inflammation in experimental neonatal brain injury and in a clinical study of preterm birth; involvement of galectin-3 and free radical formation

    Author : Christina Doverhag; Göteborgs universitet; []
    Keywords : preterm labour; premature prelabour rupture of membranes; chorioamnionitis; hypoxia-ischemia; neonatal brain injury; NADPH oxidase; galectin-3; MMP-9; ascorbyl radicals; antioxidative capacity;

    Abstract : Introduction; Intrauterine infection/inflammation is associated with preterm delivery (PTD) and severe neonatal morbidity. Inflammation is also important in the secondary neurotoxic cascade leading to perinatal brain injury. READ MORE

  5. 38. Region-specific expression of the interleukin-1 system in rat brain following endotoxin challenge and excitotoxic neurodegeneration

    Author : Charlotta Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traditionally, up-regulation and secretion of cytokines are associated with peripheral immune and inflammatory responses. There is now evidence that cytokines also exert various actions in the central nervous system (CNS). READ MORE

  6. 39. Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models

    Author : Ulrika Bergström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination and nodal/paranodal domain organization. The majority of the thesis concerns the anorectic phenotype of two mouse models for which we have found both great similarities and differences pointing to different mechanisms generating similar symptoms and neuropeptidergic alterations. READ MORE

  7. 40. 11C Molecular Imaging in Focal Epilepsy

    Author : Torsten Danfors; Eva Kumlien; Jens Sörensen; Elisabeth Ronne-Engström; Juha Rinne; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; positron emission tomography; methionine; NK1; substance p; flumazenil; deprenyl; pk11195; phosphoimager; autoradiography; TBI; traumatic brain injury; iron chloride; ferrous chloride; Neurology; Neurologi; Radiology; Radiologi;

    Abstract : Epilepsy is a common neurological disease affecting 6 million people in Europe. Early prevention and accurate diagnosis and treatment are of importance to obtain seizure freedom. In this thesis new applications of carbon-11-labelled tracers in PET and autoradiographic studies were explored in focal epilepsy. READ MORE