Search for dissertations about: "Microglial activation"
Showing result 6 - 10 of 60 swedish dissertations containing the words Microglial activation.
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6. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease
Abstract : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). READ MORE
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7. Microglia in the juvenile brain after cranial irradiation
Abstract : Radiotherapy is used to treat pediatric brain tumors and is often accompanied with debilitating late effects, such as cognitive decline. However, the mechanisms are poorly understood, and consequently there is still no effective treatment. READ MORE
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8. Beta-amyloid, tau-protein and cystatin C in the pathophysiology of Alzheimer´s disease
Abstract : Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine production and oxidative stress. READ MORE
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9. Inflammation and neurodegeneration in mouse nervous system : experimental application
Abstract : Experimental autoimmune neuritis (EAN) is a CD4+ T cell mediated inflammatory autoimmune disease of peripheral nervous system (PNS) and shares many of clinical, immunological, electrophysiological and morphological characteristics of human Guillain-Barré syndrome (GBS). Hence, EAN is considered to represent a useful model for studying the pathogenesis and therapy of human GBS. READ MORE
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10. Mitigating neuroinflammation : new potential therapeutics and targets
Abstract : Neurodegenerative disorders, from chronic diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) to more acute injuries such traumatic brain injury (TBI), present a particular challenge to public health as they lack treatments and have devastating consequences. Across the variety of central nervous system (CNS) diseases and injuries, inflammation is a hallmark and potential target for effective therapies. READ MORE