Search for dissertations about: "Microsomes"

Showing result 1 - 5 of 55 swedish dissertations containing the word Microsomes.

  2. 1. Metabolite Profiling of Drugs using Mass Spectrometry : Identification of analytical targets for doping control and improvements of the metabolite search process

    Author : Malin Nilsson Broberg; Mikael Hedeland; Ulf Bondesson; Curt Pettersson; Börje Tidstedt; Peter Van Eenoo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; UHPLC-HRMS; Doping control; Metabolite profile; SARM; Selective Androgen Receptor Modulator; MVDA; Microsomes; Experimental design; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Doping is defined as the use of prohibited substances or methods by the World Anti-Doping Agency and the aim with doping control analysis is to detect the use of these illicit substances or methods. Substances that are prohibited in human or equine sports have either a positive or negative impact on the performance. READ MORE

  4. 2. Fatty acid hydroxylation in rat kidney and liver microsomes

    Author : Åke Ellin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  5. 3. Cytochromes P-450 in biosynthesis of bile acids and metabolism of vitamin D3 : studies on cytochrome P-450 isozymes in rat liver microsomes

    Author : Stefan Andersson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  6. 4. Proteomics-informed analysis of drug disposition in the human liver and small intestine

    Author : Christine Wegler; Per Artursson; Pär Matsson; Tommy B Andersson; Manthena Varma; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; protein concentration; drug disposition; drug transport; drug metabolism; human small intestine; human liver; human hepatocytes; human liver microsomes; inter-individual variability; drug clearance; obesity; prediction model; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. READ MORE

  7. 5. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi

    Author : Shamsi D. Raeissi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. READ MORE