Search for dissertations about: "Mikael Oliveberg"

Showing result 1 - 5 of 13 swedish dissertations containing the words Mikael Oliveberg.

  1. 1. Protein folding studies of human superoxide dismutase and ALS associated mutants

    Author : Mikael Lindberg; Mikael Oliveberg; Jane Clarke; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; superoxide dismutase; ALS; protein folding; equilibrium titration; protein stability; apo protein; disulphide bridge; chevron plot; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : Proteins are among the most abundant biological macromolecules. The cellular machinery is coupled to exact structural shape and properties of the more than 100 000 different proteins. Still, proteins can sometimes completely change their character and as a result trigger neuro degenerative disease. READ MORE

  2. 2. SOD1´s Law : An Investigation of ALS Provoking Properties in SOD1

    Author : Roberth Byström; Gerhard Gröbner; Stefan Marklund; Mikael Oliveberg; Bengt-Harald Jonsson; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; amyotrophic lateral sclerosis; SOD1; protein folding; membrane interaction; aggregates; survival time; repulsive charge; Biochemistry; Biokemi;

    Abstract : Proteins are the most important molecules in the cell since they take care of most of the biological functions which resemble life. To ensure that everything is working properly the cell has a rigorous control system to monitor the proper function of its proteins and sends old or dysfunctional proteins for degradation. READ MORE

  3. 3. Folding of the Ribosomal protein S6 : The role of sequence connectivity, overlapping foldons, and parallel pathways

    Author : Ellinor Haglund; Mikael Oliveberg; Neil Ferguson; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; S6; chevron plot; transition state; parallell pathways; foldon; two-channel landscape; protein engineering; H D-exchange; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation.  In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. READ MORE

  4. 4. The birth and growth of the protein folding nucleus : Studies of protein folding focused on critical contacts, topology and ionic interactions

    Author : Linda Hedberg; Mikael Oliveberg; Christopher Johnson; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; chevron plot; transition-state movements; Hammond behaviour; topology; electrostatic interactions; pH dependence; mass-action; protein engineering; pKa; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Proteins are among the most complex molecules in the cell and they play a major role in life itself. The complexity is not restricted to just structure and function, but also embraces the protein folding reaction. READ MORE

  5. 5. Protein engineering for biophysical studies of protein folding, stability and surface interactions

    Author : Martin Karlsson; Mikael Oliveberg; Linköpings universitet; []
    Keywords : Biochemistry; protein folding; NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : The subject of this thesis can be split into two parts, one that is dealing with the stability and stabilization of proteins on its own merits and a second part that deals with the protein adsorption orientation on solid surfaces and how the stability of a protein influences the behavior at a solid/liquid interface. Thus, the common denominator and focus have been on protein stability. READ MORE