Search for dissertations about: "Mikael Oliveberg"

Showing result 6 - 10 of 17 swedish dissertations containing the words Mikael Oliveberg.

  2. 6. Protein folding without loops and charges

    Author : Martin Kurnik; Mikael Oliveberg; Kevin W. Plaxco; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein folding; folding cooperativity; protein aggregation; protein charges; protein engineering; Biochemistry; biokemi;

    Abstract : Going down the folding funnel, proteins may sample a wide variety of conformations, some being outright detrimental to the organism. Yet, the vast majority of polypeptide molecules avoid such pitfalls. Not only do they reach the native minimum of the energy landscape; they do so via blazingly fast, biased, routes. READ MORE

  4. 7. SOD1 Aggregation : Relevance of thermodynamic stability

    Author : Lisa Lang; Mikael Oliveberg; Michele Vendruscolo; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Aggregation; misfolding; Superoxide dismutase SOD1 ; Amyotrophic lateral sclerosis ALS ; unfolding; thermodynamic stability; Biochemistry; biokemi;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the upper and lower motor neurons causing muscle atrophy and paralysis followed by death. Aggregates containing superoxide dismutase (SOD1) are found as pathological hallmark in diseased ALS patients. READ MORE

  5. 8. How transient interactions in the crowded cytosol affect protein mobility and stability

    Author : Sarah Leeb; Mikael Oliveberg; Magnus Wolf-Watz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; diffusive transient interactions; macromolecular crowding; protein stability; in-cell NMR; protein evolution; Biophysics; biofysik;

    Abstract : Most biochemical reactions have evolved in crowded intracellular environments. However, the complexity of intracellular environments is often neglected in structural or functional studies of proteins. READ MORE

  6. 9. Zinc in folding and misfolding of SOD1 : Implications for ALS

    Author : Lina Leinartaité; Mikael Oliveberg; Bengt-Harald Jonsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein misfolding; local unfolding; metal binding; energy landscape; protein disease; amyotrophic lateral sclerosis; Biochemistry; biokemi;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing degeneration of upper and lower motor neurons. Most ALS cases are sporadic; only 6% are associated with mutations in Cu, Zn superoxide dismutase (SOD1). READ MORE

  7. 10. Protein Folding Studies on the Ribosomal Protein S6: the Role of Entropy in Nucleation

    Author : Magnus Lindberg; Mikael Oliveberg; Jane Clarke; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; protein folding; circular permutation; topology; connectivity; entropy; protein stability; chevron plot; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : One of the most challenging tasks remaining in the field of biochemistry is the one of understanding how the information within the amino acid sequence of proteins translates into a unique structure. Solving this problem would lead to endless possibilities for application in the medical and biotechnology industry. READ MORE