Search for dissertations about: "Mikael Sigvardsson"

Showing result 1 - 5 of 8 swedish dissertations containing the words Mikael Sigvardsson.

  1. 1. Mechanisms of mechanically induced Osteoclastogenesis in a novel in vitro model for bone implant loosening

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Cornelia Bratengeier; Anna Fahlgren; Per Aspenberg; Mikael Sigvardsson; Oran Kennedy; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Total joint arthroplasty is the primary intervention in the treatment of end-stage osteoarthritis. Despite the high success rate, in some patients, the replacement will fail during their lifetime requiring a revision of the implant. These revisions are strenuous for the patient and costly for health care. READ MORE

  2. 2. Live and Let Die Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Pernilla Eliasson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Urban Gullberg; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cells; hypoxia; self-renewal; survival; acute myeloid leukemia; FLT3; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Haematology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Hematologi;

    Abstract : The hematopoietic stem cell (HSC) is characterized by its ability to self-renew and produce all mature blood cells throughout the life of an organism. This is tightly regulated to maintain a balance between survival, proliferation, and differentiation. READ MORE

  3. 3. Hypoxia inducible factor 1 alpha dependent and independent regulation of hematopoietic stem cells and leukemia

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Camilla Halvarsson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Kamil Kranc; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : This thesis has studied the role of low oxygen levels, or hypoxia, in hematopoietic stem cells (HSCs) and how, at the molecular level, it regulates stem cell maintenance and protects against oxidative stress induced by reactive oxygen species (ROS). HSCs reside within the bone marrow in specific niches created by a unique vascularized environment, which is suggested to be hypoxic and crucial for HSCs by maintaining a quiescent state of cell cycle and by redirecting metabolism away from the mitochondria to glycolysis. READ MORE

  4. 4. Proteomics as a multifaceted tool in medicine and environmental assessment

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Jacob Kuruvilla; Susana Cristobal; Mats Lindahl; Mikael Sigvardsson; Jean Armengaud; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Proteomics is evolving as a multi-faceted tool for addressing various biochemical and biomedical queries in the field of scientific research. This involves various stages, ranging from sample preparation to data analysis and biological interpretation. READ MORE

  5. 5. Calcium regulation and functions of basic Helix-Loop-Helix transcription factors

    University dissertation from Umeå : Molekylärbiologi

    Author : Juha Saarikettu; Thomas Grundström; Dan Holmberg; Mikael Sigvardsson; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; calcium; calmodulin; calretinin; transcription; bHLH; E-protein; E2-2; Molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. READ MORE