Search for dissertations about: "Mismatch repair"

Showing result 1 - 5 of 50 swedish dissertations containing the words Mismatch repair.

2. 1. Mismatch repair deficiency in colorectal cancer : prognosis and prediction for basic treatment strategies

   Author : Ioannis Gkekas; Jan Novotny; Karin Strigård; Richard Palmqvist; Ulf Gunnarsson; Christian Sturesson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; defective mismatch repair; prognosis and prediction; Oncology; onkologi;

   Abstract : Colorectal cancer (CRC) remains a significant healthcare problem worldwide, being the third most common cancer and the fourth most frequent cause of cancer death. Environmental and dietary factors such as alcohol abuse, cigarette smoking, and genetic predisposition seem to constitute the main aetiologies. READ MORE

4. 2. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

   Author : Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

   Abstract : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. READ MORE

5. 3. Morphological Features and Mismatch Repair in Colorectal Tumors

   Author : Britta Halvarsson; Tumörmikromiljö; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; patologisk anatomi; Lynch syndrome; Colorectal tumors; HNPCC; Mismatch repaire; pathological anatomy; General pathology; Genetik; cytogenetik; cytogenetics; Genetics; Medicin människa och djur ; Medicine human and vertebrates ; Immunohistochemistry;

   Abstract : Corlorectal cancer affects 5% of individuals in the Western world and heredity is estimated to cause at least 10% of the tumors. Defective mismatch repair (MMR) is a tumorigenic mechanism through which about 15% of colorectal cancer develops and this feature characterizes tumors associated with Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch syndrome. READ MORE

6. 4. Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome

   Author : Patrick Joost; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mismatch repair; Lynch syndrome; immunohistochemistry; microsatellite instability; heterogeneity; cumulative incidence; colorectal cancer; urothelial cancer; prostate cancer; renal cell cancer;

   Abstract : Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). READ MORE

7. 5. Oxidative damage and the DNA glycosylase MutYH

   Author : Kristina Jansson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Oxidative damage; 8-oxo-7; 8-dihydro-2′-deoxyguanosine; Base excision repair; DNA glycosylase; Mismatch repair; DNA damage checkpoint; 9-1-1 complex; Glutathione-S-transferases; Colon cancer.;

   Abstract : The DNA glycosylase MutYH is highly conserved throughout evolution, and homologs are found in most eukaryotes and prokaryotes examined. MutYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), one of the most stable products of oxidative DNA damage. READ MORE