Search for dissertations about: "Mitogen activated protein kinase kinase MEK 1 2"

Showing result 1 - 5 of 6 swedish dissertations containing the words Mitogen activated protein kinase kinase MEK 1 2.

  1. 1. A Path for Improving Stroke Recovery. Effects of MEK-ERK1/2 Inhibition

    Author : Maryam Mostajeran; Lund Medicin; []
    Keywords : Ischemic stroke; Extracellular-signal regulated kinase ERK 1 2; Mitogen activated protein kinase kinase MEK 1 2; Recovery; Functional outcome; sex;

    Abstract : The present thesis aimed to shed more light on the notion of acute inhibition of extracellular-signal regulated kinase (ERK)1/2 pathway as a treatment to improve stroke recovery. Stroke is a major cause of death and long-term disability worldwide, classified as ischemic or hemorrhagic. READ MORE

  2. 2. Adenosine receptor signaling and the activation of mitogen-activated protein kinases

    Author : Gunnar Schulte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular adenosine levels with increased energy consumption. Adenosine is metabolized by adenosine deaminase and adenosine kinase. READ MORE

  3. 3. Calcium calmodulin-dependent protein kinase signal transduction in cerebral arteries

    Author : Roya Waldsee; Lund Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAMK; Ednothelin receptors; Calcium; gene regulation;

    Abstract : Cerebral arteries participate actively in the response that follows an episode of cerebral ischemia in man and rat. It has been shown that the vascular endothelin receptor expression is increased in stroke and organ culture. READ MORE

  4. 4. Gene regulation, intracellular signaling and membrane traffic : Studies in primary human skeletal muscle cultures

    Author : Lubna Al-Khalili; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

    Abstract : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. READ MORE

  5. 5. Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ

    Author : Emelie Wallerstedt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2-Diabetes; inflammation; obesity; IL-6; STAT3; PKCδ; FOXO1;

    Abstract : The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated the importance of PKCδ in 3T3-L1 adipocytes and mouse embryonic fibroblasts (MEFs) lacking protein kinase C-δ (PKCδ-/-) (Paper II). READ MORE