Search for dissertations about: "Molecular Cellbiology"

Showing result 1 - 5 of 46 swedish dissertations containing the words Molecular Cellbiology.

  1. 1. Application of Proximity Ligation Assay for Multidirectional Studies on Transforming Growth Factor-β Pathway

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Agata Zieba; Ola Söderberg; Kathleen C. Flanders; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation; TGF-β signaling; Smad; single cell analysis; cell cycle; context-dependent signaling; CRC; Molekylär cellbiologi; Molecular Cellbiology; Medicinal Chemistry; Läkemedelskemi; Molecular Biology; Molekylärbiologi;

    Abstract : A comprehensive understanding of how the body and all its components function is essential when this knowledge is exploited for medical purposes. The achievements in biological and medical research during last decades has provided us with the complete human genome and identified signaling pathways that governs the cellular processes that facilitates the development and maintenance of higher order organisms. READ MORE

  2. 2. Molecular And Cellular Networks in Critical Illness Associated Muscle Weakness Skeletal Muscle Proteostasis in the Intensive Care Unit

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Varuna Chaminda Banduseela; Lars Larsson; Gustavo Nader; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperones; autophagy; intensive care unit; heat shock proteins; protein synthesis; proteostasis; ER stress; gene expression; sepsis; neuromuscular blockers; corticosteroids; immobilisation; mechanical ventilation; Molekylär cellbiologi; Molecular Cellbiology; Molekylär medicin; Molecular Medicine;

    Abstract : Critical illness associated muscle weakness and muscle dysfunction in intensive care unit (ICU) patients lead to severe morbidity and mortality as well as significant adverse effect on quality of life. Immobilization, mechanical ventilation, neuromuscular blocking agents, corticosteroids, and sepsis have been implicated as important risk factors, but the underlying molecular and cellular mechanisms remain unclear. READ MORE

  3. 3. Nuclear pore membrane glycoprotein 210 as a new marker for epithelial cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Magnus Olsson; Neus Visa; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Nuclear pore complex; gp210; Nulp1; epithelial cells; kidney development; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Epithelial cell polarisation is a prerequisite for the branching morphogenesis in several organs. Differential screening techniques were used to identify genes, which are upregulated during induction of epithelium in early kidney development. READ MORE

  4. 4. Specific signaling through heteromeric PDGF receptor complexes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Simon Ekman; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. READ MORE

  5. 5. Mechanisms for TGF-β-Mediated Regulation of the Actin Filament System and Apoptosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Edlund; Pontus Aspenström; Maréne Landström; Tommy Andersson; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-beta; cytoskeleton; GTPases; mitogen-activated protein kinase kinase 3; TGF-beta-activated kinase 1; Apoptosis; Smad7; beta-catenin; p38 MAPK; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Transforming growth factor-β (TGF-β) is a member of a large superfamily of cytokines which participate in many different types of cellular processes, such as growth inhibition, cell migration, differentiation, cell adhesion, wound healing and immunosuppression. Alterations of TGF-β superfamily signalling results in several different disorders, including bone disease, vascular disease and cancer. READ MORE