Search for dissertations about: "Molecular chaperone"

Showing result 1 - 5 of 99 swedish dissertations containing the words Molecular chaperone.

  1. 1. Type III secretion- the various functions of the translocon operon in bacterial pathogenesis

    University dissertation from Umeå : Molekylärbiologi

    Author : Jeanette E Bröms; Umeå universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Yersinia; Pseudomonas aeruginosa; type III secretion; chaperone; translocation; regulation; lcrGVHyopBD; pcrGVHpopBD; Molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : In order to establish colonisation of a human host, pathogenic Yersinia use a type III protein secretion system to directly intoxicate host immune cells. Activation of this system requires target cell contact and is a highly regulated process. READ MORE

  2. 2. The Chaperonin Containing TCP-1 : Interactions with the Mammalian Cytoskeleton

    University dissertation from Umeå : Molekylärbiologi

    Author : Karen I. Brackley; Göteborgs universitet.; Gothenburg University.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular chaperone; Cytoskeleton;

    Abstract : The eukaryotic Chaperonin Containing TCP-1 (CCT) is a heterooligomeric chaperonin essential for enabling the cytoskeletal proteins actin and tubulin to fold to their native state. The eight CCT subunits are encoded by individual genes and are present in cells as the ~960kDa oligomer, as components of micro-complexes, and as monomeric subunits. READ MORE

  3. 3. Molecular Aspects of Transthyretin Amyloid Disease

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Karin Sörgjerd; Per Hammarström; Joel Buxbaum; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid; apoptosis; BiP; chaperone; misfolding; oligomer; transthyretin; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Abstract : This thesis was made to get a deeper understanding of how chaperones interact with unstable, aggregation prone, misfolded proteins involved in human disease. Over the last two decades, there has been much focus on misfolding diseases within the fields of biochemistry and molecular biotechnology research. READ MORE

  4. 4. Human copper ion transfer from metal chaperone to target transporter domain

    University dissertation from Umeå : Umeå Universitet

    Author : Moritz Sebastian Niemiec; Umeå universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; copper homeostasis; copper chaperone; Atox1; ATP7B; Wilson disease protein; metal transport; size exclusion chromatography; thermodynamics; isothermal calorimetry;

    Abstract : Many processes in living systems occur through transient interactions among proteins. Those interactions are often weak and are driven by small changes in free energy. READ MORE

  5. 5. The Extended Role of the Molecular Chaperone CCT

    University dissertation from Umeå : Umeå Universitet

    Author : Andreas Svanstrom; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; CCT oligomer; Actin; CCT delta; CCT epsilon; Gelsolin; MRTF-A; Cell morphology;

    Abstract : The oligomeric chaperone CCT is a large ATP-dependent chaperonin that consists of two rings placed back-to-back with eight different paralogous subunits with a size of ~ 55 kDa that sit in each of the two rings. The function of CCT is mainly to fold the abundant proteins actin and tubulin, components of the cytoskeleton. READ MORE