Search for dissertations about: "Molecular serum"

Showing result 1 - 5 of 335 swedish dissertations containing the words Molecular serum.

2. 1. Modulators of Vibrio cholerae predator interaction and virulence

   Author : Barbro Lindmark; Sun Nyunt Wai; Kristian Riesbeck; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; Caenorhabditis elegans; PrtV; outer membrane vesicles; non-O1 non-O139; serum resistance; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Vibrio cholerae, the causal agent of cholera typically encodes two critical virulence factors: cholera toxin (CT), which is primarily responsible for the diarrhoeal purge, and toxin-co-regulated pilus (TCP), an essential colonisation factor. Nontoxigenic strains expressing TCP can efficiently acquire the CT gene through lysogenic conversion with CTXΦ, a filamentous phage that encodes CT and uses TCP as a receptor. READ MORE

4. 2. Genetic and molecular dissection of hemolymph coagulation and melanization in Drosophila melanogaster

   Author : Gawa Bidla; Ulrich Theopold; David Schneider; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

   Abstract : Injury to epithelial barriers puts metazoans at risk of loss of body fluid and contamination of their body by foreign particles. This risk is even exacerbated in insects, which have an open circulatory system and as a result, quickly need to seal wounds in order to keep a fairly constant internal milieu. READ MORE

5. 3. Development of molecular recognition by rational and combinatorial engineering

   Author : Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

   Abstract : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. READ MORE

6. 4. Human intestinal alkaline phosphatase : tissue expression and serum levels

   Author : Ulla Domar; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human alkaline phosphatase; intestinal alkaline phosphatase; blood; blood group; lipid; monoclonal antibody; immunohistochemistry; liver; kidney; pancreas; liver disease; inflammatory bowel disease;

   Abstract : Human alkaline phosphatase (ALP) comprises four isozymes, viz liver/bone/ kidney or tissue unspecific (AP), intestinal (LAP), placental (PLAP) and germ cell or PLAP-like alkaline phosphatase, with their main expression in specific tissues as indicated by their names. The isozymes are coded by different genes, but they are closely related, with more than 50% amino acid sequence homologies. READ MORE

7. 5. Molecular serum portraits - A step towards personalized medicine

   Author : Anders Carlsson; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GBM; SLE; breast cancer; Antibody microarrays; personalized medicine; serum biomarkers;

   Abstract : Antibody microarray technology has the potential for playing a large roll in identifying serological biomarker panels for personalized medicine. The aim of this thesis, based on four original papers, was to investigate if information in the serum proteome could be extracted and used for diagnostic, classificational, prognostic or treatment predictive purposes in a range of diseases. READ MORE