Search for dissertations about: "Molekylär medicin"

Showing result 16 - 20 of 634 swedish dissertations containing the words Molekylär medicin.

  2. 16. Defining the importance of protein geranylgeranylation in innate immunity

    Author : Murali K Akula; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAAX proteins; GGTase-I; RAC1; statins;

    Abstract : RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed to target proteins to membranes where they encounter effector molecules that stimulate GTP-binding and activation. READ MORE

  4. 17. Protein kinase STK25 is a regulator of hepatic lipid partitioning and whole body metabolism

    Author : Manoj Amrutkar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NAFLD; NASH; Liver lipid metabolism; Type 2 diabetes; STK25;

    Abstract : In past decade, type 2 diabetes (T2D) and associated metabolic complications have become a major global threat for human health with epidemic increase in incidence. Currently available treatments for T2D have several limitations and side effects making it difficult safely reach adequate metabolic control. READ MORE

  5. 18. Factors influencing prognosis in acute coronary syndrome - A report from the SWEDEHEART registry

    Author : Oskar Angerås; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute coronary syndrome; acute myocardial infarction; risk factors; obesity paradox; socioeconomic status; cardiogenic shock; thrombus aspiration; SWEDEHEART; SCAAR; RIKS-HIA;

    Abstract : Background: Acute coronary syndrome (ACS) is one of the major causes of mortality in the world. The prognosis for patients with ACS is affected by several factors, such as baseline characteristics and treatment before, during and after hospitalisation. . READ MORE

  6. 19. Clinical relevance of high-sensitive Troponin T in cardiovascular disease

    Author : Christian Bjurman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; prognostic score; mortality; heart failure; myocardial infarction; renal dysfunction;

    Abstract : Background and aims: Troponin T (hs-cTnT) is a cardiac damage marker used in the diagnosis of non-ST segment elevation myocardial infarction (NSTEMI) and for prognostic assessment. Clinical decision-making should ideally be based on evidence. READ MORE

  7. 20. Susceptibility to chronic liver disease

    Author : Maria Antonella Burza; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic liver disease; susceptibility; human genetics; NAFLD; ALD; PNPLA3;

    Abstract : The onset and the progression of chronic liver disease involve environmental and genetic factors. Hepatic stellate cells (HSCs) are important players in these processes and are the main storage site for retinol. READ MORE