Search for dissertations about: "Monkeys"
Showing result 11 - 15 of 66 swedish dissertations containing the word Monkeys.
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11. The role of virus neutralization in primate lentivirus pathogenesis
Abstract : The antiviral neutralizing activity of sera from primate lentivirus-infected human and monkey hosts was studied. In addition, factors affecting the neutralization reaction were investigated. In simian immunodeficiency virus (SIVsm)-infected macaque monkeys, SIVsm variants able to escape neutralization emerged regularly. READ MORE
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12. Methods for detection of HIV-2/SIV infections
Abstract : The main objective of this thesis was to develop and improve laboratory methods for detection of HIV-2 in infected humans and detection of HIV-2/SIV in experimentally infected cynomolgus monkeys. Early in the HIV epidemic no assays were commercially available for detection of HIV-2/SIV infections and laboratory testing often relied on cross-reactivity in the assays. READ MORE
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13. CD8alpha/alpha+ T-cells and immune memory
Abstract : A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered to represent a TCR co-receptor, it may rather represent a mechanism to modulate T-cell avidity and identify a subset of memory T-cells. READ MORE
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14. HIV and SIV specific cellular immunity in macaque models
Abstract : Cellular immunity is believed to be an important prerequisite for an effective HIV vaccine. Accruing data from individuals able to contain HIV-1 replication during natural infection underscores the contribution of CD8+ T cells in viral control. READ MORE
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15. Virus tropism and neutralization response in SIV infection
Abstract : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. READ MORE