Search for dissertations about: "Monoclonal Antibodies"

Showing result 11 - 15 of 319 swedish dissertations containing the words Monoclonal Antibodies.

  2. 11. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes

    Author : Sofia Söllvander; Lars Lannfelt; Anna Erlandsson; Frida Ekholm-Pettersson; Linda Söderberg; Pär Gellerfors; Martin Hallbeck; Uppsala universitet; []
    Keywords : Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Abstract : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. READ MORE

  4. 12. HIV-1 reverse transcriptase activity assays based on monoclonal antibodies to native enzyme : Applications on studies of antiviral substances and immunological variation of reverse transcriptase

    Author : Ann-Sofie Rytting; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; HIV-1; reverse transcriptase; monoclonal antibody; activity assay; subtype; RT inhibitor; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Specific detection of HIV-1 reverse transcriptase (RT) activity in crude materials was enhanced using a capture assay for immunopurification and subsequent activity assay. The purification step was achieved by anti-HIV-1 RT monoclonal antibodies (Mabs) immobilized onto a solid carrier. READ MORE

  5. 13. Monoclonal antiparathyroid antibodies identifying a calcium receptor mechanism : studies on tissue distribution, structure and function

    Author : Claes Juhlin; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  6. 14. Aβ Conformation Dependent Antibodies and Alzheimer's Disease

    Author : Dag Sehlin; Lars Lannfelt; Frida Ekholm Pettersson; David Teplow; Uppsala universitet; []
    Keywords : Alzheimer s disease; amyloid-beta; protofibrils; conformation; monoclonal antibody; ELISA; MEDICINE; MEDICIN; Geriatrics; Geriatrik;

    Abstract : Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with a particular focus on the Aβ protofibril, which has served as the antigen for developing conformation dependent monoclonal antibodies. READ MORE

  7. 15. Functional studies of anti-gpi monoclonal antibodies and anti-citrullinated protein antibodies (ACPAS)

    Author : Taotao Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over time if left untreated. READ MORE