Search for dissertations about: "Monoclonal Antibodies"
Showing result 16 - 20 of 319 swedish dissertations containing the words Monoclonal Antibodies.
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16. Expression and interaction studies of recombinant human monoclonal antibodies
Abstract : The highly specific binding characteristics of monoclonal antibodies (mAbs) have made them one of the most useful tools in the fields of research and biotechnology where they provide the basis for a large number of diagnostic and technical assays. In recent years, with the advent of techniques to generate fully human antibodies, mAbs have also emerged as a new important class of therapeutics. READ MORE
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17. Monoclonal antibodies to human interferon-α and interferon-γ : Characterization and application with focus on interferon-γ as a T cell cytokine
Abstract : The major functions of the immune system are to combat infections and to control that normal auto-immunity does not turn into auto-aggression. Antibodies, together with T cell receptors and MHC molecules, dictates the immunological specificity. READ MORE
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18. Early diagnosis of cytomegalovirus infection using monoclonal antibodies and DNA amplification
Abstract : Human cytomegalovirus (HCMV) is ubiquitous and frequently infects normal individuals with few serious clinical consequences. However, patients with impaired cellular immunity frequently develop life-threatening opportunistic HCMV infections due to either primary infection or reactivation of latent virus. READ MORE
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19. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications
Abstract : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. READ MORE
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20. Polyneuropathy associated with monoclonal gammopathy : A clinical, neurophysiological and immunological study
Abstract : This thesis is based upon clinical, neurophysiological, and immunological studies of polyneuropathy (symmetrical impairment of sensory and motor nerve function) in patients with monoclonal gammopathies, that is, patients characterized by proliferation of a plasma-cell clone secreting homogeneous immWloglobulins (M-component), which in some patients has serum antibody reactivity against peripheral nerve myelin.The prevalence of clinical polyneuropathy in patients with monoclonal gammopathy (n=3) was 36%, and the prevalence of all forms of polyneuropathy including patients with neurophysiological signs only andpatients with probable polyneuropathy (signs but no symptoms) was 58%. READ MORE