Search for dissertations about: "Monoclonal immunology"

Showing result 21 - 25 of 48 swedish dissertations containing the words Monoclonal immunology.

  2. 21. Radiolabeling and Biotinylation of Internalizing Monoclonal Antibody Chimeric BR96: Potential Use for Extracorporeal Immunoadsorption

    Author : Jianqing Chen; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; Immunologi; transplantation; Immunology; serology;

    Abstract : In this thesis, methodology of radiolabeling and simultaneous biotinylation for internalizing monoclonal antibody (MAb) chimeric BR96 (chiBR96) have been investigated by using three element groups of potential therapeutic radionuclides iodine, indium and rhenium, and their different labeling methods. The biodistribution and kinetics of biotinylated and radiolabeled chiBR96 have been studied in colon carcinoma isografted rats. READ MORE

  4. 22. Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1

    Author : Annika Pettersson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Immunologi; Immunology; serology; antibodies; BLT1; LTB4;

    Abstract : Infection and inflammation are characterized by the release of chemotactic substances that activate cells of the immune system. One of these important mediators is LTB4, an arachidonic acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and degranulation. READ MORE

  5. 23. Human monoclonal antibody technology. A tool to investigate human antibody repertoires

    Author : Mats Ohlin; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The development of technologies to generate cell lines producing monoclonal antibodies of human origin has a great impact on the ability to study repertoires of specificities in the humoral immune response. Furthermore, it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications and which lack some of the disadvantages of similar murine antibodies. READ MORE

  6. 24. Exploring Monoclonal Antibody Action Against the Group A Streptococcal M Protein

    Author : Sebastian Wrighton; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; group A streptococcus; Streptococcus pyogenes; fibronectin; phagocytosis; innate immunity; antibodies; adaptive immunity;

    Abstract : Group A Streptococcus (GAS) is a significant human pathogen that has developed multipleimmune evasion mechanisms to counter the host immune response. One of these mechanisms involvesthe production of the M protein, which, amongst other things, acts as an anti-phagocytic factor and canbind host proteins. READ MORE

  7. 25. Structural pathology and functional analysis of vitamin K-dependent protein S

    Author : Tusar K Giri; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; Protein S; blood coagulation; thrombosis; natural mutations; in vitro characterization.; Immunology; transplantation; serologi; Immunologi; serology;

    Abstract : Protein S deficiency is an autosomal dominant trait affecting around 10% of families thrombophilic families. The high affinity interaction of approximately 60% of protein S with C4b -binding protein (C4BP) has raised a complicated situation for the diagnosis of deficiency states. READ MORE