Advanced search

Showing result 1 - 5 of 8 swedish dissertations matching the above criteria.

2. 1. Synthesis of Ring-fused Peptidomimetics : Interacting with Amyloid Fibrils

   Author : Dan E. Adolfsson; Fredrik Almqvist; Anna Linusson; Morten Grötli; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; synthesis; peptidomimetics; thiazoline fused 2-pyridones; Alzheimer s disease; Parkinson s disease; Amyloid; Amyloid-beta; alfa-Synuclein; method development; organisk kemi; Organic Chemistry;

   Abstract : Parkinson's and Alzheimer's disease are the two most common neurological disorders in humans. Both conditions involve progressive death of neurons in the central nervous system, decline in bodily functions and eventually (and invariably), death. So far, no cure exists and the available treatments can only ease symptoms. READ MORE

4. 2. Development of HIV-1 Protease Inhibitors and Palladium-Catalyzed Synthesis of Aryl Ketones and N-Allylbenzamides

   Author : Linda Axelsson; Mats Larhed; Anders Karlén; Luke Odell; Morten Grötli; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; palladium; aminocarbonylation; aryl ketones; decarboxylation; HIV; protease inhibitor; tertiary alcohol; macrocycles; Medicinal Chemistry; Läkemedelskemi;

   Abstract : The use of palladium-catalyzed reactions to introduce new carbon-carbon bonds is a fundamental synthetic strategy that has been widely embraced due to its high chemo- and regioselectivity and functional group tolerance. In this context, Pd(0)-catalyzed aminocarbonylations using Mo(CO)6 instead of toxic and gaseous CO and with allylamine as the nucleophile were investigated. READ MORE

5. 3. Light-Triggered Conformational Switches for Modulation of Molecular Recognition : Applications for Peptidomimetics and Supramolecular Systems

   Author : Magnus Blom; Adolf Gogoll; Morten Grötli; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bisporphyrin tweezers; peptidomimetics; host-guest systems; conformational analysis; supramolecular chemistry; photochemistry; Organisk kemi; Organic Chemistry; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

   Abstract : The main focus of this thesis is on photochemical modulation of molecular recognition in various host-guest systems. This involves the design, synthesis and integration of light-triggered conformational switches into peptidomimetic guests and molecular tweezer hosts. READ MORE

6. 4. The MHC-glycopeptide-T cell interaction in collagen induced arthritis : a study using glycopeptides, isosteres and statistical molecular design in a mouse model for rheumatoid arthritis

   Author : Lotta Holm; Jan Kihlberg; Morten Grötli; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Rheumatoid arthritis; collagen; T-cell; class II MHC; solid phase peptide synthesis; glycopeptide; peptide isostere; PCA; statistical molecular design; PLS; QSAR; sequence binding motif; Organic chemistry; Organisk kemi;

   Abstract : Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population in the western world. It is characterised by a tissue specific attack of cartilage in peripheral joints. Collagen induced arthritis (CIA) is one of the most commonly used animal models for (RA), with similar symptoms and histopathology. READ MORE

7. 5. Photoswitchable Peptidomimetics : Synthesis and Photomodulation of Functional Peptides

   Author : Miranda Varedian; Adolf Gogoll; Morten Grøtli; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; β-hairpin; peptidomimetics; stilbene; thioaurone; photochemistry; Organic chemistry; Organisk kemi;

   Abstract : The secondary structure of peptides is of pivotal importance for their biological function. The introduction of photoswitchable moieties into the backbones of peptides provides a unique way of regulating their conformation using an external stimulus, i.e., light. READ MORE