Search for dissertations about: "Mostafa Abdalkhalik"

Found 1 swedish dissertation containing the words Mostafa Abdalkhalik.

  1. 1. Oligomerization of human and bacterial frataxin : Structural and functional studies

    University dissertation from Lund University, Faculty of Science, Department of Chemistry, Division of Biochemistry and Structural Biology

    Author : Mostafa Abdalkhalik; [2017-02]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

    Abstract : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. READ MORE