Search for dissertations about: "Mouse Lymphoma Cells"

Showing result 1 - 5 of 40 swedish dissertations containing the words Mouse Lymphoma Cells.

2. 1. Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay : Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells

   Author : Rikard Åsgård; Björn Hellman; Leif Busk; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolic syndrome; fruit and vegetable intake; plasma antioxidants; beta-carotene; alpha-tocopherol; inflammation; oxidative DNA damage; lipid peroxidation; mouse lymphoma assay; ROS; nucleotide pool; viability; DNA dye; Toxicology; Toxikologi;

   Abstract : Diet and oral supplements comprise two distinct sources of antioxidants known to prevent oxidative stress. Beneficial effects from antioxidants have been seen for patients at risk for type 2 diabetes.The aim of this thesis was to evaluate the positive effects of antioxidants against oxidative stress and DNA damage in type 2 diabetes subjects. READ MORE

4. 2. Establishment and characterization of a murine T-cell lymphoma/leukemia model

   Author : Ann-Sofie Johansson; Dan Holmberg; Magnus Lindskog; Finn Skou Pedersen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mouse model; T-cell lymphoma; Moloney murine leukemia virus; proviral integration; lymphomagenesis; COX-2; omega 3; Oncology; Onkologi; onkologi; Oncology;

   Abstract : Mouse models of human disease are valuable tools for studying pathogenesis and for evaluating novel therapies. T-cell lymphoma is a relatively rare disease in humans, affecting 100-150 persons yearly in Sweden. It exists in both aggressive and more indolent forms. READ MORE

5. 3. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets

   Author : Tor Persson Skare; Lena Claesson-Welsh; Mats Hellström; Elin Sjöberg; Jonas Fuxe; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histidine-rich glycoprotein; T cell-specifik adaptor; Lymphoma; Glioblastoma; Vascular permeability;

   Abstract : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. READ MORE

6. 4. Chemically Induced DNA Damage in Extended-term Cultures of Human Lymphocytes

   Author : Maria Andersson; Björn Hellman; Leif Busk; Uppsala universitet; []
   Keywords : Toxicology; Comet assay; DNA-damaging agents; DNA repair; Extended-term Cultures of Human Lymphocytes; Genotoxicity; Induced DNA damage; In vitro; Mouse Lymphoma Cells; Primary Cell Cultures; Reactive Oxygen Species; Toxikologi;

   Abstract : Generation of DNA damage is regarded to be an important initial event in the development cancer. Consequently, a battery of tests have been developed to detect different types of genotoxic effects in order to be able to predict the potential genotoxicity and mutagenicity of chemicals, including both pharmaceutical drugs and various types of environmental and occupational agents, as well as dietary factors. READ MORE

7. 5. Investigating the function of Anaplastic Lymphoma Kinase

   Author : Emma Vernersson Lindahl; Bengt Hallberg; Ruth Palmer; Göran Roos; Carina Hellberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALK; nervous system; knockout; development; Jelly-Belly; Pathology; Patologi;

   Abstract : Anaplastic Lymphoma Kinase (ALK) was discovered in 1994, as a chromosomal translocation, t(2;5)(p23;q35), often seen in Anaplastic Large Cell Lymphomas (ALCL). Since then ALK has been extensively studied in this disease as well as in different model organisms. READ MORE