Search for dissertations about: "Mouse Models"

Showing result 11 - 15 of 623 swedish dissertations containing the words Mouse Models.

  2. 11. Novel Treatment Modalities for High-Risk Neuroblastoma : Studies in Animal Models

    Author : Dieter Fuchs; Faranak Azarbayjani; Rolf Christofferson; Sven Påhlman; Uppsala universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; neuroblastoma; bevacizumab; SU11248; GMX1778; GMX1777; animal model; Medicine; Medicin;

    Abstract : Neuroblastoma, the most common extracranial solid tumor of childhood, is a heterogeneous tumor. In some patients, the tumor can go into spontaneous regression and disappear whereas other patients have rapidly growing tumors with a poor prognosis. READ MORE

  4. 12. Vascular Interactions in Innate Immunity and Immunothrombosis: : Models of Endothelial Protection

    Author : Sofia Nordling; Peetra Magnusson; Paul Kubes; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endothelial cells; Thrombosis; Innate immunity; Immunothrombosis; Thromboinflammation; Immunologi; Immunology;

    Abstract : The phenomenon known as immunothrombosis has garnered increased attention over the last few years. Much work has been done to characterize the cross talk between hemostasis and the innate immune system. READ MORE

  5. 13. Fcγ Receptors in the Immune Response

    Author : Teresita Díaz de Ståhl; Jan van de Winkel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Fc Receptors; IgG Receptors; IgE Receptors; Immune regulation; In vivo animal models; Mouse; Rh prophylaxis; Rheumatoid arthritis; Transgenic knockout; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Circulating immune complexes play an important role in the modulation of antibody responses and in the pathogenesis of immune diseases. This thesis deals with the in vivo regulatory properties of antibodies and their specific Fc receptors. READ MORE

  6. 14. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials

    Author : Elin Forsberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; uveal melanoma; patient-derived xenograft; immune-humanized mouse model; immunotherapy; adoptive T cell therapy; tumor-infiltrating lymphocytes; chimeric antigen receptor T CAR-T cells;

    Abstract : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. READ MORE

  7. 15. Automated behavioral phenotyping of inbred mouse strains and mouse models of Alzheimer disease

    Author : Alina Codita; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Behavioral characterization of various mouse strains created as models for human diseases such as Alzheimer disease requires robust phenotyping methods. Previous work on inbred mouse strains has shown that some of the widely used behavioral methods yield inconsistent results across laboratories, in spite of standardization efforts. READ MORE