Search for dissertations about: "Mouse strains"

Showing result 6 - 10 of 161 swedish dissertations containing the words Mouse strains.

  2. 6. Functions of Heparan Sulfate During Mouse Development : Studies of Mice with Genetically Altered Heparan Sulfate Biosynthesis

    Author : Maria Ringvall; Lena Kjellén; Erik Forsberg; Ulf Lindahl; Erika Gustafsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; embryonic development; gene targeting; lung development; ossification; heparan sulfate; heparin; N-deacetylase N-sulfaotransferase; NDST; proteoglycan; morphogen; biosynthesis; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Abstract : Heparan sulfate (HS) is a ubiquitous polysaccharide on the cell surface and in the extracellular matrix. HS is an important actor in the regulation of cell signaling, especially in the developing embryo. READ MORE

  4. 7. The Complex Genetics of Mouse Reproduction and Arhritis

    Author : Maria Liljander; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; morula; B10.Q mice; genetics.; Pregnancy; CIA; reproduction; QTL; superovulation; blastocysts; oocytes; litter size; RA; NFR N mice; MHC;

    Abstract : ABSTRACT Optimal breeding of mice is very important in biomedical science today. The understanding why some strains breed better and some worse enable scientists to create better in vivo models for human diseases. READ MORE

  5. 8. Structural investigation of SOD1 aggregates in ALS : identification of prion strains using anti-peptide antibodies

    Author : Johan Bergh; Thomas Brännström; Stefan L. Marklund; Peter M. Andersen; Joakim Bergström; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; prion; motor neuron disease; neurodegeneration; strain; seeding; protein aggregation; transgenic mice; peptide antibodies; Neurology; neurologi;

    Abstract : Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative syndrome characterized by progressive degeneration of motor neurons that result in muscle wasting. The symptoms advance gradually to paralysis and eventually death. Most patients suffer from sporadic ALS (sALS) but 10% report a familial predisposition. READ MORE

  6. 9. Home-cage monitoring of mouse behaviours across life-span

    Author : Karin Pernold; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background and aim: The academic research involving animal testing is struggling with problems of reproducibility and a few of the specific reasons pointed out are for example insufficient reporting of animal strains and protocol details. It is everyone’s responsibility to follow the 3R’s (Replace, Reduce, Refine) and to ensure that the model used is well characterized. READ MORE

  7. 10. Corticosteroid receptors and Na,K-ATPase in the developing mouse cochlea

    Author : Susan Erichsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : inner ear; stria vascularis; endolymph production; Na; K-ATPase; glucocorticoid receptor; mineralocorticoid receptor; knockout mouse; shaker-2; mix; immunohistochemistry;

    Abstract : The senses of hearing and equilibrium are highly dependent on the fluid and electrolyte homeostasis in the inner ear. The characteristic intracellular-like ionic composition of endolymph fluid in relation to the surrounding perilymph creates the endocochlear potential (EP), which is a prerequisite for inner ear function. READ MORE