Search for dissertations about: "Muc2"

Showing result 6 - 10 of 22 swedish dissertations containing the word Muc2.

  2. 6. O-glycosylation of intestinal and respiratory mucins in health and disease

    Author : Jessica Holmén Larsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucins; oligosaccharide; O-linked glycosylation; mass spectrometry; MUC2; Fut2 enzyme; Nippostrongylus brasiliensis infection; Cystic Fibrosis; Ulcerative colitis;

    Abstract : Mucins are large glycoproteins with a diverse O-glycosylation constituting up to 80% of the total mucin mass. The mucus layer covering the epithelial cells of the gastrointestinal and respiratory tract is largely made up of gel-forming mucins. READ MORE

  4. 7. Alterations of mucin O-glycosylation in response to intestinal infection. Importance of specific glycosyltransferases

    Author : Fredrik J. Olson; Göteborgs universitet; []
    Keywords : mucins; altered O-glycosylation; Nippostrongylus brasiliensis infection; blood group A glycosyltransferase; Muc2; MUC1; GalNAc-T4; mass spectrometry;

    Abstract : Mucins are large glycoproteins constituting the major protein component of the mucus layer covering the epithelial surfaces. The mucins are characterised by a dense and heterogeneous O-glycosylation, important for their chemical and physiological properties. READ MORE

  5. 8. Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis

    Author : Karolina S. Jabbar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucus; Mass spectrometry; MUC2; MUC5AC; IPMN; Pancreatic cysts; Ulcerative colitis; IBS; Brachyspira;

    Abstract : Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against infection and inflammation, but may also contribute to carcinogenesis and tumour progression. READ MORE

  6. 9. Microcirculation, Mucus and Microbiota in Inflammatory Bowel Disease

    Author : Olof Schreiber; Lena Holm; Mia Phillipson; Henrik Sjövall; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammatory bowel diseases; experimental colitis; DSS; TNBS; colonic mucosal blood flow; laser-doppler flowmetry; colonic mucus thickness; MUC2; colonic mucosal barrier function; iNOS; eNOS; probiotics; Lactobacilli; Lactobacillus reuteri; colonic microbiota; T-RFLP; bacterial translocation; intravital microscopy; P-selectin; leukocyte recruitment; platelet recruitment; Physiology; Fysiologi; Physiology; Fysiologi;

    Abstract : Inflammatory bowel diseases, (IBD), are a group of chronic disorders of the gastro-intestinal tract, and include Crohn’s disease (CD) and Ulcerative Colitis (UC). The pathogenesis is not known, but involves at least in part a loss of tolerance towards the commensal colonic microbiota. READ MORE

  7. 10. Biomarker mRNAs for staging and prognosis of colorectal cancer

    Author : Lina Ohlsson; Marie-Louise Hammarström; John Shively; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; immunologi; Immunology;

    Abstract : Mesenteric lymph node (ln) metastasis is the single most important prognostic characteristic in colorectal cancer (CRC). The ln status is used for staging and is a decisive selection criterion for postoperative adjuvant therapy. However, it is difficult to accurately determine ln status by routine histopathology (H&E). READ MORE