Search for dissertations about: "Multiple Sclerosis"

Showing result 21 - 25 of 308 swedish dissertations containing the words Multiple Sclerosis.

  2. 21. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

    Author : Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. READ MORE

  4. 22. Chronic sorrow and quality of life in patients with multiple sclerosis

    Author : Ann-Kristin Isaksson; Gerd Ahlström; Lars-Gunnar Gunnarsson; Siv Söderberg; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; illness experience; diagnosis experience; impairment; health-related quality of life; subjective quality of life; immunological treatment; chronic sorrow; depression; managing chronic illness; content analysis; well-being; Caring sciences; Vårdvetenskap; Vårdvetenskap; Nursing Science;

    Abstract : The overall aim of this thesis was to increase our understanding and knowledge of patients’ experiences of living with multiple sclerosis (MS). A mixed-method design was used, including both qualitative and quantitative methods. READ MORE

  5. 23. Hematopoietic Stem Cell Transplantation for Treatment of Multiple Sclerosis in Sweden

    Author : Christina Zjukovskaja; Joachim Burman; Kim Kultima; Susanna Brauner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AHSCT; HSCT; hematopoietic stem cell transplantation; multiple sclerosis; RRMS; inflammation; biomarkers; АТГСК; ТГСК; Трансплантация гемопоэтических стволовых клеток; рассеянный склероз; воспаление; биомаркеры; AHSCT; HSCT; Hematopoetisk stamcellstransplantation; multipel skleros; RRMS; inflammation; biomarkör; Medicinsk vetenskap; Medical Science;

    Abstract : This thesis investigated the efficacy and safety of autologous hematopoietic stem cell transplantation (AHSCT) as a treatment of multiple sclerosis. This thesis demonstrates that when compared to one of the most powerful disease-modifying drugs (DMDs), specifically alemtuzumab (ALZ), AHSCT is able to hold its ground. READ MORE

  6. 24. Walking ability, balance and accidental falls in persons with Multiple Sclerosis

    Author : Ylva Nilsagård; Lars-Gunnar Gunnarsson; Eva Denison; Katrin Boström; Christina H. Opava; Örebro universitet; []
    Keywords : multiple sclerosis; cooling garment; gait; walking; balance; reliability; validity; accidental falls; prediction; ICF; MEDICINE; MEDICIN; Medicin; Medicine;

    Abstract : By using a pragmatic paradigm, different research methodologies were employed in this thesis. MS-related symptoms may be exaggerated due to heatsensitivity and it is supposed that cooling garments relieve the symptoms. READ MORE

  7. 25. Multiple Sclerosis: Studies of the Interferon system and search for infectious agents

    Author : My Bergkvist; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; Axon and myelin damage; IgG; Virus; Interferon; Multiple Sclerosis; Genetic linkage;

    Abstract : Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. READ MORE