Search for dissertations about: "Multiple endocrine neoplasia type 1"

Showing result 1 - 5 of 22 swedish dissertations containing the words Multiple endocrine neoplasia type 1.

  2. 1. Multiple endocrine neoplasia type 1 : clinical, biochemical and genetic investigations

    Author : Britt Skogseid; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. Pancreatic Endocrine Tumourigenesis : Genes of potential importance

    Author : Térèse A. Johansson; Barbro Eriksson; Britt Skogseid; Gunnar Westin; Martin Bäckdahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic endocrine tumour; Multiple endocrine neoplasia type 1; Tumourigenesis; Notch signalling; Notch1; Hes1; Neurog3; Neurod1; Men1; Ascl1; Pou3f4; Pdx1; Rpl10; Dlk1; Dkk1; Tph1; menin; Tumour biology; Tumörbiologi;

    Abstract : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. READ MORE

  5. 3. Molecular studies of multiple endocrine neoplasia type 1 (MEN1)

    Author : Shideh Khodaei-O'Brien; Karolinska Institutet; Karolinska Institutet; []
    Keywords : genetics; MEN1; cancer; tumor suppressor gene; cDNA selection; mutation; menin; ortholog; evolution; conservation; expression; RNA; protein; RT-PCR;

    Abstract : Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors of the parathyroids, the endocrine pancreas and anterior pituitary. The MEN1 locus has been previously localized to chromosome 11q13 and subsequently a MEN1 minimum region was defined by a combination of linkage and tumor deletion studies. READ MORE

  6. 4. Multiple endocrine neoplasia type 1 : clinical and molecular characterization

    Author : Bin Tean Teh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEN1; PYGM; loss of heterozygosity; thymic carcinoid; HPT-JT; HRPT2; FIHP; familial acromegaly; tumor suppressor gene.;

    Abstract : This thesis is based on clinicopathologic and genetic studies of MEN1 and MEN1-like syndromes. Linkage to the MENl locus in chromosome 11q13 was confirmed in the largest known MEN1 family and 5 Swedish MEN1 families. An accuracy of >99. READ MORE

  7. 5. Functional studies of the multiple endocrine neoplasia type 1 gene

    Author : Lovisa Bylund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEN1; menin; tumor suppressor gene; cancer; RNAi; promoter; expression; cytogenetic; microarray;

    Abstract : The multiple endocrine neoplasia type 1 (MEN1, OMIM 131 100) syndrome is an autosomal dominant trait with a near 100% penetrance and with an estimated prevalence of 2-20/100 000. The syndrome is characterized by neoplasia affecting the parathyroid glands (90-97%), enteropancreatic endocrine tissues (30-80%) and the anterior pituitary gland (15-50%) but tumors arc also found in other, both endocrine and non endocrine tissues. READ MORE