Search for dissertations about: "Multiplexed assays"
Showing result 1 - 5 of 22 swedish dissertations containing the words Multiplexed assays.
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1. On the application and validation of multiplexed affinity assays
Abstract : Proteins are essential macromolecules that carry out complex functions in human cells, tissues, and organs. They regulate a diverse set of biological processes and protect against pathogens. However, dysregulation or malformation of proteins can cause disease. READ MORE
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2. Solid-phase Proximity Ligation Assays : High-performance and multiplex protein analyses
Abstract : Protein biomarkers circulating in blood hold the promise of improved diagnosis, prognosis and follow-up of treatment of disease via minimally invasive procedures. For the discovery and validation of such biomarkers, methods are needed that can facilitate parallel, highly specific and in-depth analysis of the blood proteome. READ MORE
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3. Novel methods for improving rapid paper-based protein assays with gold nanoparticle detection
Abstract : This thesis describes methods for improving sensitivity in rapid singleplex and multiplex microarray assays. The assays utilize the optical characteristics of colloidal gold nanoparticles for the colorimetric detection of proteins.Multiplexed detection in sandwich immunoassays is limited by cross-reactivity between different detection antibodies. READ MORE
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4. Proximity Ligation Assays for Disease Biomarkers Analysis
Abstract : One of the pressing needs in the field of disease biomarker discovery is new technologies that could allow high performance protein analysis in different types of clinical material, such as blood and solid tissues. This thesis includes four approaches that address important limitations of current technologies, thus enabling highly sensitive, specific and parallel protein measurements. READ MORE
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5. Affinity assays for profiling disease-associated proteins in human plasma
Abstract : Affinity-based proteomics offers opportunities for the discovery and validation of disease-associated proteins in human body fluids. This thesis describes the use of antibody-based immunoassays for multiplexed analysis of proteins in human plasma, serum and cerebrospinal fluid (CSF). READ MORE