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Showing result 1 - 5 of 142 swedish dissertations matching the above criteria.
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1. Deciphering sequence data : A multivariate approach
Abstract : In this thesis, attention has been focused on the quantitative description of nucleic acids, proteins and peptides. The strategy was to use multivariate chemometrical methods for improving the understanding of the complex structural codes of these kinds of biological molecules. READ MORE
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2. Decoding the complex brain : multivariate and multimodal analyses of neuroimaging data
Abstract : Functional brain images are extraordinarily rich data sets that reveal distributed brain networks engaged in a wide variety of cognitive operations. It is a substantial challenge both to create models of cognition that mimic behavior and underlying cognitive processes and to choose a suitable analytic method to identify underlying brain networks. READ MORE
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3. Multivariate design of molecular docking experiments : An investigation of protein-ligand interactions
Abstract : To be able to make informed descicions regarding the research of new drug molecules (ligands), it is crucial to have access to information regarding the chemical interaction between the drug and its biological target (protein). Computer-based methods have a given role in drug research today and, by using methods such as molecular docking, it is possible to investigate the way in which ligands and proteins interact. READ MORE
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4. Multivariate Measurements and Chemical Imaging of Organic Compounds
Abstract : Chemical imaging is an emerging analytical technique, based on the interplay between, most often, spectroscopic measurements and advanced evaluation methodology. With this we can study the distribution of chemical compounds in different compartments, such as individual cells and pharmaceutical tablets. READ MORE
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5. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications
Abstract : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. READ MORE