Search for dissertations about: "Mutagenicity"

Showing result 11 - 15 of 19 swedish dissertations containing the word Mutagenicity.

  2. 11. Chemically Induced DNA Damage in Extended-term Cultures of Human Lymphocytes

    Author : Maria Andersson; Björn Hellman; Leif Busk; Uppsala universitet; []
    Keywords : Toxicology; Comet assay; DNA-damaging agents; DNA repair; Extended-term Cultures of Human Lymphocytes; Genotoxicity; Induced DNA damage; In vitro; Mouse Lymphoma Cells; Primary Cell Cultures; Reactive Oxygen Species; Toxikologi;

    Abstract : Generation of DNA damage is regarded to be an important initial event in the development cancer. Consequently, a battery of tests have been developed to detect different types of genotoxic effects in order to be able to predict the potential genotoxicity and mutagenicity of chemicals, including both pharmaceutical drugs and various types of environmental and occupational agents, as well as dietary factors. READ MORE

  4. 12. Cancer and male reproductive function- the effect on sperm DNA integrity and on birth outcomes in the offspring

    Author : Olof Ståhl; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SCSA; birth outcomes; sperm DNA integrity; male cancer; fertility;

    Abstract : Male cancer survivors (MCS) are at risk of suffering from impaired fertility. Male fertility is dependant on sperm DNA quality. The Sperm Chromatin Structure Assay (SCSA) reflects the proportion of sperm with poor DNA, the DNA fragmentation index, DFI. READ MORE

  5. 13. Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay : Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells

    Author : Rikard Åsgård; Björn Hellman; Leif Busk; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolic syndrome; fruit and vegetable intake; plasma antioxidants; beta-carotene; alpha-tocopherol; inflammation; oxidative DNA damage; lipid peroxidation; mouse lymphoma assay; ROS; nucleotide pool; viability; DNA dye; Toxicology; Toxikologi;

    Abstract : Diet and oral supplements comprise two distinct sources of antioxidants known to prevent oxidative stress. Beneficial effects from antioxidants have been seen for patients at risk for type 2 diabetes.The aim of this thesis was to evaluate the positive effects of antioxidants against oxidative stress and DNA damage in type 2 diabetes subjects. READ MORE

  6. 14. Toxicological and endocrinolgical aspects of cytochrome P450 in breast and lung

    Author : Heike Hellmold; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cytochrome P450; breast; lung; metabolism;

    Abstract : Cytochrome P450 (CYP) enzymes have well characterized functions in disposition and pharmacokinetics of xenobiotics as well as in biosynthesis and/or metabolism of endogenous compounds, such as steroid hormones, bile acids, arachidonic acid and its derivatives. Cytochrome P450 mediated metabolic activation is known to be a prerequisite for the cytotoxic and mutagenic activity of many environmental toxins and procarcinogens. READ MORE

  7. 15. Interplay between DNA repair pathways at replication forks in mammalian cells

    Author : Fredrik Johansson; Dag Jenssen; Klaus Erixon; Harry Vrieling; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Abstract : Cellular DNA is continuously being damaged by various agents of both endogenous and exogenous origin including a wide range of chemical compounds, UV-light and ionizing radiation. In order to remove lesions from the DNA and maintain genomic stability, different repair processes have evolved. READ MORE