Search for dissertations about: "Mutagenicity"

Showing result 6 - 10 of 19 swedish dissertations containing the word Mutagenicity.

  2. 6. Genotoxic hazards in the rubber industry : application of short-term tests in work environment analyses

    Author : Agneta Rannug; Stockholms universitet; []
    Keywords : ;

    Abstract : Excess mortality from a number of different types of cancer has been associated with work in the rubber industry. The aim of the present study - using short-term tests for mutagenicity - was to identify potentially hazardous additives and process fumes to which workers are exposed. READ MORE

  4. 7. Mutagenesis induced by xenobiotics : factors of importance and modification, with special emphasis on glutathione and glutathione transferases

    Author : Lennart Romert; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetics; genetik;

    Abstract : Genetic changes induced by chemical agents can result in cancer. Such tumor formation can be linked to activationof oncogenes, often through specific, definable mutagenic events, e.g., single base-pair mutation in specific codons. READ MORE

  5. 8. A strategy for ranking environmentally occuring chemicals

    Author : Lennart Eriksson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; QSAR; hazard ranking; statistical design; multivariate modelling; halogenated aliphatics; PCA; PLS;

    Abstract : A systematic methodology for quantitative structure-activity relationship (QSAR) development in environmental toxicology is provided. The methodology is summarized in a strategy with six sequential steps. READ MORE

  6. 9. Factors Influencing the Yield of Mutations Induced by Polycyclic Aromatic Hydrocarbons in Mammalian Cells

    Author : Anne Lagerqvist; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Hanspeter Naegeli; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologisk genetik; Toxicological Genetics;

    Abstract : Environmental contaminants are ubiquitously present in the urban environment, this has the implication that humans are exposed to toxic and carcinogenic chemicals. Polycyclic aromatic hydrocarbons (PAH) are one type of environmental contaminants, which are produced by combustion of organic compounds. READ MORE

  7. 10. Evolving the Methodology for Detection of Primary DNA Damage : Development, adaptation and assessment of the single cell gel electrophoresis (comet) assay

    Author : Erik Bivehed; Björn Hellman; Hanna Karlsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Comet assay; DNA damage; DNA strand breaks; Flash-comet; Genotoxicity; In vitro; Single cell gel electrophoresis; Polymerase assisted DNA damage assay PADDA ; TK6 cells; UCDAS; U937 cells; Toxikologi; Toxicology; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Deoxyribonucleic acid (DNA) is one of the most important molecules in nature. It is the fundamental carrier of evolutionary information and constitutes the genetic blueprint of all living organisms. Being the sole source of information, it is vital for the cell to transmit the correct genetic information from generation to generation. READ MORE