Search for dissertations about: "Mutation patterns"
Showing result 1 - 5 of 117 swedish dissertations containing the words Mutation patterns.
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1. Mutation and immune profiling of non-small cell lung cancer
Abstract : Several novel therapies that target molecular alterations and immune checkpoints in lung cancer have been introduced in the last decade. Still, only a minority of patients obtain long term disease control and overall survival remains poor. READ MORE
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2. Bioinformatic Analysis of Mutation and Selection in the Vertebrate Non-coding Genome
Abstract : The majority of the vertebrate genome sequence is not coding for proteins. In recent years, the evolution of this noncoding fraction of the genome has gained interest. These studies have been greatly facilitated by the availability of full genome sequences. READ MORE
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3. Rates and Patterns of Mutation in Microsatellite DNA
Abstract : Sequence comparisons of orthologous microsatellite loci in cattle and sheep revealed that the substitution rate in microsatellite flanking sequences does not differ from the rate in presumably neutrally evolving intron sequences. This suggests that microsatellites are generally located in regions that are not subjected to selection. READ MORE
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4. Mutation and Diversity in Avian Sex Chromosomes
Abstract : Sex chromosomes are useful for the study of how factors such as mutation, selection, recombination and effective population size affect diversity and divergence.A comparison of gametologous introns in seven different bird species revealed a complete lack of diversity on the female-specific W chromosome. READ MORE
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5. Nucleotide Substitution Patterns in Vertebrate Genomes
Abstract : The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. READ MORE