Search for dissertations about: "Mutation"

Showing result 21 - 25 of 1253 swedish dissertations containing the word Mutation.

  2. 21. Genetic variability of hepatitis B virus in chronic infection

    Author : Charles Hannoun; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; mutation; genotype; phylogeny; ; Recombination; coinfection; interferon; response;

    Abstract : Chronic hepatitis B is a major health problem, and may lead to cirrhosis and hepatocellular carcinoma. The liver damage in hepatitis B virus (HBV) infection is considered to be a result of the immune response, and not a cytopathic effect of the virus itself. READ MORE

  4. 22. Short and long-term effects of exposure to low dose and low dose rate of gamma radiation : using in vitro and in vivo models

    Author : Traimate Sangsuwan; Siamak Haghdoost; Eva Forssell-Aronsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Low dose; Low dose rate; High dose rate; Ionizing radiation; Adaptive response; Senescence; Premature senescence; Oxidative stress; Drosophila embryo; Mutation; DNA repair; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Assessment of human health risks from exposure to ionizing radiation (IR) is mainly based on the extrapolation of results from epidemiological studies on populations exposed to relatively high doses and often at high dose rates (HDR). Risk estimates after exposure to low doses and in particular at low dose rates (LDR) remain controversial due to a lack of epidemiological evidence. READ MORE

  5. 23. A Multitype Branching Processes Approach to the Evolutionary Dynamics of Escape

    Author : Maria Conceicao Serra; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galton-Watson branching processes; multitype; decomposable processes; population dynamics; extinction; mutation; path to escape; waiting time to escape; Galton-Watson branching processes;

    Abstract : Evolutionary dynamics of escape is a recent development in theoretical biology. It is an attempt to predict possible patterns of population dynamics for a certain strain of viruses placed in a hostile environment. The only way to escape extinction for the virus is to find a new form better adapted to the new environment. READ MORE

  6. 24. Quantitative analysis of disease associated mutations and sequence variants

    Author : Charlotta Olsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Kvantifiering; PCR-metoder; SNP; mutation; Genetik; Clinical genetics; Klinisk genetik; Molecular Medicine; molekylär medicin genetik och patologi ;

    Abstract : A solid-phase sequencing technique was applied to quantify the mitochondrial A3243G mutation in three families with maternally inherited diabetes and deafness. A correlation between the level of heteroplasmy and age at onset was found. READ MORE

  7. 25. Detection and analysis of genetic alterations in normal skin and skin tumours

    Author : Åsa Sivertsson; KTH; []
    Keywords : single cell; DNA sequencing; p53; mutation; UV; BCC; pyrosequencing; malignant melanoma; N-ras;

    Abstract : The investigation of genetic alterations in cancer-relatedgenes is useful for research, prognostic and therapeuticpurposes. However, the genetic heterogeneity that often occursduring tumour progression can make correct analysischallenging. READ MORE