Search for dissertations about: "Mutation"
Showing result 6 - 10 of 1253 swedish dissertations containing the word Mutation.
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6. Pathogenic Mechanisms of the Arctic Alzheimer Mutation
Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, neuropathologically characterized by neurofibrillay tangles and deposition of amyloid-β (Aβ) peptides. Several mutations in the gene for amyloid precursor protein (APP) cause familial AD and affect APP processing leading to increased levels of Aβ42. READ MORE
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7. Mutation Analysis and Hypercholesterolemia: Studies in FH patients and in healthy middle-aged men with high, low, or increasing cholesterol levels during a six-year follow-up (the CRISS study)
Abstract : Our aims were to characterize familial hypercholesterolemia (FH) in a Swedish FH population and to further elucidate the clinical expression and treatment response in relation to genotype. Secondly, we wanted to identify gene variants, which may have impact on cholesterol levels in apparently healthy subjects. READ MORE
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8. A Mutation-based Framework for Automated Testing of Timeliness
Abstract : A problem when testing timeliness of event-triggered real-time systems is that response times depend on the execution order of concurrent tasks. Conventional testing methods ignore task interleaving and timing and thus do not help determine which execution orders need to be exercised to gain confidence in temporal correctness. READ MORE
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9. Biosensor technology applied to hybridization analysis and mutation detection
Abstract : This thesis demonstrates the application of biosensor technology for molecular biology investigations, utilizing a surface plasmon resonance based optical device for mass sensitive detection of biomolecular interactions at a chipsurface. Oligonucleotide model systems were designed for analysis of the action of DNA manipulating enzymes. READ MORE
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10. Molecular Genetic Alterations In Endometrial And Ovarian Cancers
Abstract : Endometrial cancer is the most common gynecological cancer diagnosed in western countries. Complex atypical hyperplasia (CAH) reflects a state of hyperestrinism and its role as a precursor lesion of this cancer is established. READ MORE