Search for dissertations about: "Mutational signatures"
Showing result 1 - 5 of 14 swedish dissertations containing the words Mutational signatures.
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1. Computational studies of mutational sequence signatures in cancer genomes
Abstract : Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational signatures have emerged in the last decade as essential tools for analysis of mutational processes. READ MORE
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2. Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma
Abstract : Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. READ MORE
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3. The leukocyte complexity and mutational landscape of periampullary adenocarcinoma. Morphology matters
Abstract : Background: Periampullary adenocarcinomas are a heterogenous group of tumours with poor prognosis that hasnot improved considerably the last decades. Tumour morphology, i.e. intestinal type (I-type) or pancreatobiliarytype (PB-type), has been demonstrated to be a more relevant prognostic factor than anatomical origin. READ MORE
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4. Characterization of the genome and tumor microenvironment of human B-cell lymphoma
Abstract : Non-Hodgkin lymphoma (NHL) is the 13th most common type of cancer worldwide in 2020 and consists mainly of human B-cell lymphoma (approximately 85%). Diffuse large B-cell lymphoma (DLBCL) is the most common NHL subtype (approximately 30%). READ MORE
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5. Genetic and molecular mechanisms of sarcomas
Abstract : Sarcomas are heterogeneous malignant mesenchymal tumors with diverse biological features and unique clinical characteristics, the genetic alterations of sarcomas are highly variable. With the development of sequencing technologies, efficient and practical approaches to detect gene expressions and gene variants contribute to the prediction of patient prognosis and the choice of treatment modalities. READ MORE