Search for dissertations about: "Myc"
Showing result 6 - 10 of 178 swedish dissertations containing the word Myc.
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6. Assessment of therapeutic targets in experimental models of Myc-induced lymphoma
Abstract : The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. READ MORE
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7. Regulation and function of the Mad/Max/Myc network during neuronal and hematopoietic differentiation
Abstract : The Mad/Max/Myc transcription factor network takes part in the control of vital cellular functions such as growth, proliferation, differentiation and apoptosis. Dimerization with the protein Max is necessary for the Myc-family of oncoproteins and their antagonists, the Mad-family proteins, to regulate target genes and carry out their intended functions. READ MORE
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8. The Myc network of growth regulators and its interplay with growth and differentiation signals
Abstract : The proto-oncogenes/tumor suppressor genes of the Myc/N4ax/Mad network encode transcription factors that are important regulators of cell growth, differentiation, and apoptosis and that are frequently implicated in tumor development. Regulation of their biological functions by growth/differentiation signals as well as their interplay with growth/differentiation signalling pathways play important roles in cell fate determination. READ MORE
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9. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies
Abstract : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. READ MORE
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10. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor
Abstract : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. READ MORE