Search for dissertations about: "Mycobacterium smegmatis Bacteria"

Showing result 1 - 5 of 7 swedish dissertations containing the words Mycobacterium smegmatis Bacteria.

  2. 1. Dynamic Organization of Molecular Machines in Bacteria

    Author : Bhupender Singh; Santanu Dasgupta; Leif A. Kirsebom; Don G. Ennis; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular machines; bacteria; cell cycle; ribosome; replisome; divisome; spore; E. coli; H. pylori; Mycobacteria; Microbiology; Mikrobiologi; Mikrobiologi; Microbiology;

    Abstract : Bacterial cells were once treated as membrane-enclosed bags of cytoplasm: a homogeneous, undifferentiated suspension in which polymers (proteins, nucleic acids, etc.) and small molecules diffused freely to interact with each other. READ MORE

  4. 2. Enzymes in the Mycobacterium tuberculosis MEP and CoA Pathways Targeted for Structure-Based Drug Design

    Author : Christofer Björkelid; T. Alwyn Jones; Torsten Unge; Sherry L. Mowbray; William N. Hunter; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Tuberculosis; Mycobacterium tuberculosis; MEP pathway; CoA pathway; drug development; crystal structure; DXR; IspD; PanK; Biokemi; Biochemistry; Molecular Biology; Molekylärbiologi;

    Abstract : Tuberculosis, caused by the pathogenic bacteria Mycobacterium tuberculosis, is one of the most widespread and deadly infectious diseases today. Treatment of tuberculosis relies on antibiotics that were developed more than 50 years ago. These are now becoming ineffective due to the emergence of antibiotic resistant strains of the bacteria. READ MORE

  5. 3. Wiring Components of the Respiratory Chain : Modulation of the Respiratory Chain in Yeast and Bacteria

    Author : Jacob Schäfer; Peter Brzezinski; Dennis Winge; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cytochrome c oxidase; Electron transfer; Membrane protein; Ligand; Kinetics; Mechanism; Rcf1; Cytochrome c; Respiratory supercomplex; Cryo-electron microscopy; Biochemistry; biokemi;

    Abstract : The enzyme complexes of the respiratory chain are organized in supramolecular assemblies, so-called respiratory supercomplexes. In the yeast Saccharomyces cerevisiae, these supercomplexes consist of two copies of complex III (bc1 complex) and one or two copies of complex IV (cytochrome c oxidase, CytcO). READ MORE

  6. 4. Activation of neutrophils by mycobacteria and mycobacterial components

    Author : Jenny Fäldt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human neutrophils; mycobacteria; oxygen radicals; cytokines; mycobacterial glycolipids; priming;

    Abstract : The genus Mycobacterium includes free-living saprophytes, opportunists, and human pathogens.Mycobacterium tuberculosis, the organism causing tuberculosis, as well as other pathogenicmycobacteria can survive and multiply inside phagocytic cells, but the underlying mechanisms areonly partly understood. READ MORE

  7. 5. Structural and Biochemical Characterizations of Three Potential Drug Targets from Pathogens

    Author : Lu Lu; Sherry L Mowbray; Alwyn Jones; Christian Cambillau; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LepB; DXR; NDH-2; fosmidomycin; quinolinyl pyrimidine; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : As antibiotic resistance of various pathogens emerged globally, the need for new effective drugs with novel modes of action became urgent. In this thesis, we focus on infectious diseases, e.g. READ MORE