Search for dissertations about: "Mycobacterium smegmatis"

Showing result 1 - 5 of 12 swedish dissertations containing the words Mycobacterium smegmatis.

  1. 1. Fighting Tuberculosis – : Structural Studies of Three Mycobacterial Proteins

    Author : Alina Castell; Torsten Unge; Manfred Weiss; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mycobacterium tuberculosis; Rv0216; Rv0130; Mycobacterium smegmatis; branched chain aminotransferase; X-ray crystallography; fatty acid metabolism; Structural biology; Strukturbiologi;

    Abstract : This thesis presents the cloning, purification, crystallization, and structural studies of two unknown proteins from Mycobacterium tuberculosis, and of an aminotransferase from Mycobacterium smegmatis. Structural knowledge of these proteins is of highest interest for structure-based drug design, which is one of the approaches that can be used in order to fight tuberculosis (TB). READ MORE

  2. 2. Enzymes in the Mycobacterium tuberculosis MEP and CoA Pathways Targeted for Structure-Based Drug Design

    Author : Christofer Björkelid; T. Alwyn Jones; Torsten Unge; Sherry L. Mowbray; William N. Hunter; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Tuberculosis; Mycobacterium tuberculosis; MEP pathway; CoA pathway; drug development; crystal structure; DXR; IspD; PanK; Biokemi; Biochemistry; Molecular Biology; Molekylärbiologi;

    Abstract : Tuberculosis, caused by the pathogenic bacteria Mycobacterium tuberculosis, is one of the most widespread and deadly infectious diseases today. Treatment of tuberculosis relies on antibiotics that were developed more than 50 years ago. These are now becoming ineffective due to the emergence of antibiotic resistant strains of the bacteria. READ MORE

  3. 3. Studies of wild types and induced mutants of Mycobacterium phlei strains PA and PN, now reclassified as Mycobacterium smegmatis and Rhodococcus bronchialis on the basis of biochemical data

    Author : Ada Kolman; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  4. 4. Defense-peptides against mycobacteria

    Author : Charlotte MA Linde; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Antimicrobial peptides; NK-lysin; granulysin; PR-39; Mycobacterium;

    Abstract : Several members of the genus Mycobacterium can cause serious infections in both man and animal. One of the world's most serious infectious diseases, tuberculosis, is caused by the pathogen Mycobacterium tuberculosis. Specific defense to tuberculosis/mycobacteriosis is dependent on the individual's ability to mount a proficient immune response. READ MORE

  5. 5. Enzyme catalysis towards bio-based UV-curable buildingblocks

    Author : Maja Finnveden; Mats Martinelle; Katja Loos; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; Enzyme; Enzymatic Polymerizations; Biocatalysis; Lipase; CalB; MsAcT; Substrate specificity; Selectivity; Polymer Chemistry; UV-curring; Biotechnology; Bioteknologi;

    Abstract : Polymeric materials are found in virtually all areas of daily life; they are found in everything from packages keeping our food safe to the buildings where we spend our days, and the production is a worldwide industry. Although polymeric materials play a big part in sustainable solution’s, a lot can be done to develop more environmental methods for producing them. READ MORE