Search for dissertations about: "Myxoid round cell liposarcoma"

Found 5 swedish dissertations containing the words Myxoid round cell liposarcoma.

  1. 1. Molecular studies of genetic changes in myxoid and round cell liposarcoma

    University dissertation from Sofia Thelin-Järnum, BMC I12, 221 84 Lund, Sweden

    Author : Sofia Järnum; Lunds universitet.; Lund University.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; oncology; Cytology; autocrine loop; RDA; persephin; RET; LEPREL1; translocation; fusion gene; liposarcoma; TLS; CHOP;

    Abstract : Popular Abstract in Swedish Människans arvsmassa består av DNA. DNA i sin tur består av nukleotiderna A, T, G och C som i olika kombinationer bygger upp våra gener. Människans "genom" (hela arvsmassa) består av uppåt 100 000 gener och varje gen kodar för ett protein som i sin tur är byggstenarna i våra kroppar. READ MORE

  2. 2. Liposarcomas - proliferation, senescence and the role of DDIT3

    University dissertation from Sofia Thelin-Järnum, BMC I12, 221 84 Lund, Sweden

    Author : Christina Kåbjörn-Gustafsson; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liposarcoma; FUS-DDIT3; TP53; senescence;

    Abstract : Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. READ MORE

  3. 3. Clinical and molecular studies of liposarcoma

    University dissertation from Sofia Thelin-Järnum, BMC I12, 221 84 Lund, Sweden

    Author : Katarina Engström; Göteborgs universitet.; Gothenburg University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liposarcoma; radiotherapy; prognostic factors; transfection; FUD-DDIT3; adipogenesis; microarray expression analysis; cell cycle; immunohistochemistry;

    Abstract : Aims: (1) To analyse clinicopathological characteristics, treatment and outcome of liposarcoma, and to determine whether, and how, the Scandinavian Sarcoma Group (SSG) treatment guidelines were followed; (2) to analyse tumour volume and morphology response after radiotherapy in myxoid/round cell liposarcoma (MLS/RCLS); (3) to examine the role of the MLS-specific fusion gene FUS-DDIT3 in development of liposarcomas; and (4) to analyse expression patterns of cell cycle regulating proteins in MLS. Methods: (1) A total of 319 liposarcomas reported between 1986?1998 to the SSG Register were reviewed. READ MORE

  4. 4. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

    University dissertation from Sofia Thelin-Järnum, BMC I12, 221 84 Lund, Sweden

    Author : Melker Göransson; Göteborgs universitet.; Gothenburg University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

    Abstract : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. READ MORE

  5. 5. FET proteins in cancer and development

    University dissertation from Sofia Thelin-Järnum, BMC I12, 221 84 Lund, Sweden

    Author : Mattias K Andersson; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FUS; EWS; TAF15; FUS-DDIT3; myxoid liposarcoma; NF-κB; NFKBIZ; FLT1; CDK2;

    Abstract : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. READ MORE