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Found 5 swedish dissertations matching the above criteria.

  2. 1. Molecular studies of genetic changes in myxoid and round cell liposarcoma

    Author : Sofia Järnum; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; oncology; Cytology; autocrine loop; RDA; persephin; RET; LEPREL1; translocation; fusion gene; liposarcoma; TLS; CHOP;

    Abstract : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. READ MORE

  4. 2. Liposarcomas - proliferation, senescence and the role of DDIT3

    Author : Christina Kåbjörn-Gustafsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liposarcoma; FUS-DDIT3; TP53; senescence;

    Abstract : Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. READ MORE

  5. 3. Clinical and molecular studies of liposarcoma

    Author : Katarina Engström; Göteborgs universitet; []
    Keywords : Liposarcoma; radiotherapy; prognostic factors; transfection; FUD-DDIT3; adipogenesis; microarray expression analysis; cell cycle; immunohistochemistry;

    Abstract : Aims: (1) To analyse clinicopathological characteristics, treatment and outcome of liposarcoma, and to determine whether, and how, the Scandinavian Sarcoma Group (SSG) treatment guidelines were followed; (2) to analyse tumour volume and morphology response after radiotherapy in myxoid/round cell liposarcoma (MLS/RCLS); (3) to examine the role of the MLS-specific fusion gene FUS-DDIT3 in development of liposarcomas; and (4) to analyse expression patterns of cell cycle regulating proteins in MLS. Methods: (1) A total of 319 liposarcomas reported between 1986?1998 to the SSG Register were reviewed. READ MORE

  6. 4. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

    Author : Melker Göransson; Göteborgs universitet; []
    Keywords : Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

    Abstract : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. READ MORE

  7. 5. FET proteins in cancer and development

    Author : Mattias K Andersson; Göteborgs universitet; []
    Keywords : FUS; EWS; TAF15; FUS-DDIT3; myxoid liposarcoma; NF-κB; NFKBIZ; FLT1; CDK2;

    Abstract : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. READ MORE