Search for dissertations about: "N-cadherin"

Showing result 16 - 20 of 20 swedish dissertations containing the word N-cadherin.

  2. 16. Ready to pull : force transmission during vascular development

    Author : Yuanyuan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The transmission of mechanical forces controls a multitude of cellular processes such as migration, the formation of new organs, muscle contraction, and resistance to the continuous stress that blood flow exerts on the blood vessel wall. These forces are sensed and replayed at the sites of cellular adhesion to the basal membrane as well as cell-cell junctions, where protein complexes connect to the cellular cytoskeleton to relay force into the cell. READ MORE

  4. 17. Brain Inflammation and Adult Hippocampal Neurogenesis in Epilepsy

    Author : Deepti Chugh; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Inflammation; Neurogenesis; Hippocampus; Microglia; Adhesion molecules; Scaffolding proteins;

    Abstract : Epilepsy is a severe chronic neurological disorder characterized by recurrent spontaneous seizures. Excitatory/inhibitory (E/I) imbalance, neuronal loss, brain inflammation, and altered adult neurogenesis are some of the characteristic hallmarks of epilepsy. READ MORE

  5. 18. Different types of γ-secretes complexes and their effect on substrate processing

    Author : Annelie Pamrén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide (Aβ) from the amyloid precursor protein (APP). The γ-secretase complex cleaves APP at two different sites (γ- and ε-sites) generating Aβ-peptides and the APP intracellular domain (AICD). READ MORE

  6. 19. Studies on gamma-secretase activity and products

    Author : Jenny Frånberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein (APP) generates the APP intracellular domain (AICD) and the amyloid beta-peptide (Abeta). READ MORE

  7. 20. Wnt signaling in early brain development and disease

    Author : Panagiotis Papachristou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Wnt/Planar Cell Polarity (PCP) signaling is involved in many cellular processes throughout the development of the embryo. These include control of proliferation, differentiation, migration and cell fate decisions. Deregulation of Wnt/PCP signaling can lead to many developmental abnormalities and cancer. READ MORE