Search for dissertations about: "N-linked glycosylation"

Showing result 1 - 5 of 33 swedish dissertations containing the words N-linked glycosylation.

  1. 1. Studies on N-linked glycosylation in proliferation and viability of normal and tumor cells in vitro

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Magdalena Carlberg; Karolinska Institutet.; Karolinska Institutet.; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; DNA synthesis; IGF-1 receptor; HMG-CoA reductase; lovastatin; mevalonate; N-linked glycosylation; PDGF; SV40-transformation; tumor; tunicamycin.;

    Abstract : STUDIES ON N-LINKED GLYCOSYLATION IN PROLIFERATION ANDVIABILITY OF NORMAL AND TUMOR CELLS IN VITROby Magdnlena CarlbergUnit of Tumor Pathology, Department of Oncology and Pathology, Karolinska Institute,S-l 71 77 Stockholm, Sweden.A number of studies suggest a critical role of N-linked glycosylation for cellularproliferation. READ MORE

  2. 2. N-linked glycosylation of HIV-1 and Hantaan virus glycoproteins. Implications for vaccination and therapy

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Eric Rowcliffe; Göteborgs universitet.; Gothenburg University.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Enveloped viruses have a great advantage comparedto the non-enveloped viruses due to theirability to acquire not only a host membrane butalso host-specific glycosylation of their surfaceglycoproteins. These carbohydrate structures,mainly of the N-linked glycan class, have a lowimmunogenicity and this feature enables envelopedviruses to keep a low profile towards theimmune system by shielding crucial epitopesfrom antibody recognition. READ MORE

  3. 3. Role of dolichyl phosphate, N-linked glycosylation and cell membrane expression of insulin-like growth factor-1 receptor in maintenance of malignant cell growth

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Anica Dricu; Karolinska Institutet.; Karolinska Institutet.; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : ROLE OF DOLICHYL PHOSPHATE, N-LINKED GLYCOSYLATION AND CELLMEMBRANE EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR IN MAINTENANCE OF MALIGNANTCELL GROWTH Several studies have demonstrated that mevalonate (MVA) synthesis is requiredfor cell proliferation. The mechanisms underlying MVA-regulated cell growth are stillnot fully understood. READ MORE

  4. 4. Intrapatient evolution of HIV-1 in the context of coreceptor usage

    University dissertation from Lund University, Faculty of Medicine Doctoral Dissertation Series

    Author : Mattias Mild; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coreceptor switch; Medicine human and vertebrates ; Medicin människa och djur ; biological cloning; R5-X4; coreceptor usage; glycosylation; recombination; HIV; evolution;

    Abstract : The variable region 1 to 3 (V1-V3) of the HIV-1 envelope plays an important role in coreceptor usage. Early in infection HIV- 1 is using CCR5 as coreceptor to enter target cells (R5 viruses) whereas viruses using CXCR4 as coreceptor (X4 viruses) may appear later in infection. READ MORE

  5. 5. Immune recognition and early virus-cell interactions. Glycobiological aspects on HIV-1 gp120

    University dissertation from Göteborg

    Author : Gregers J. Gram; Göteborgs universitet.; Gothenburg University.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human immunodeficiency virus type 1 HIV-1 ; glycoprotein; gp120; glycosylation.;

    Abstract : Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the etiological agents of AIDS in humans. The viral envelope glycoproteins gp120 and gp41 mediate the early virus-cell interaction of HIV with the target cells. READ MORE