Search for dissertations about: "N-linked glycosylation"
Showing result 16 - 20 of 35 swedish dissertations containing the words N-linked glycosylation.
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16. Characterization and Crystallization of Anchorless Glypican-1
Abstract : Glypicans are cell-surface heparan sulfate proteoglycans that regulate Wnt, Hedgehog, bone morphogenetic protein, and fibroblast growth factor signaling through their heparan sulfate chains. Recent studies have shown that glypican core proteins also have functional roles in growth factor signaling, but biochemical and structural knowledge regarding the core proteins is limited. READ MORE
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17. HIV-1 phenotype and genetic variation in vertical transmission
Abstract : HIV-1 vertical transmission is increasing worldwide despite that successful strategies are available. Reduction of vertical transmission has been established by antiretroviral prophylaxis and elective Caesarian section, but this has been limited to the developed countries. READ MORE
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18. Growth factor pathways in human cancer : functional and therapeutic implications
Abstract : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. READ MORE
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19. HIV-1 envelope protein gp120. Glycovirology of the V3 loop
Abstract : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. READ MORE
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20. HIV-2 genetic evolution and viral dynamics
Abstract : HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In this thesis we have investigated different aspects of HIV-2 in order to understand the pathogenesis of HIV-2 better. READ MORE