Search for dissertations about: "N-linked glycosylation"

Showing result 6 - 10 of 35 swedish dissertations containing the words N-linked glycosylation.

  2. 6. Clusterin in brain and cerebrospinal fluidin Alzheimer s disease

    Author : Anna-Maria Nilselid; Göteborgs universitet; []
    Keywords : Alzheimer s disease; clusterin; apolipoprotein J; SP-40; brain tissue; cerebrospinal fluid; glycosylation; biomarker; enzyme-linked immunosorbent assay;

    Abstract : The apolipoprotein clusterin is suggested to be involved in the pathogenesis of Alzheimer¡¦s disease (AD). At the start of these studies, results had indicated that clusterin was elevated in AD brain, compared with controls. READ MORE

  4. 7. Aspects of N-glycosylation in human IgE

    Author : Johanna Da Luz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The medical interest of allergy in industrialised societies has generated a much greater knowledge about the pathophysiology of IgE-mediated responses than about its normal physiological role. Because of the central role of IgE in allergic inflammation, neutralisation of effector functions and inhibition of IgE-synthesis are attractive means of therapy. READ MORE

  5. 8. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications

    Author : Thi Thuy Tran; Gunnar Thorsén; McLean John; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microfluidic CD; therapeutic antibodies; post-translational modifications; glycosylation profiling; multivariate statistical analysis; MALDI-MS; Analytical Chemistry; analytisk kemi;

    Abstract : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. READ MORE

  6. 9. Targeting and function of CAH1 : Characterization of a novel protein pathway to the plant cell chloroplast

    Author : Stefan Burén; Göran Samuelsson; Muriel Bardor; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Arabidopsis; chloroplast; endomembrane system; CAH1; protein targeting; N-glycosylation; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The chloroplast is the organelle within a plant cell where photosynthesis takes place. This organelle originates from a cyanobacterium that was engulfed by a eukaryotic cell. READ MORE

  7. 10. Glypican-1: Structural and functional analysis of the N-glycosylated human protein

    Author : Wael Awad Abdelhady; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Proteoglycans; glypicans; glypican-1; heparan sulphate; N-glycosylation; exostosin-proteins; X-ray crystallography; crystal dehydration; diffraction anisotropy; Small angle X-ray scattering SAXS9; protein spectroscopy;

    Abstract : Glypicans are multifunctional cell surface heparan sulphate proteoglycans co-regulating numerous signalling pathways, and are thereby involved in the control of cellular division, differentiation, and morphogenesis. The heparan sulphate (HS) chains are responsible for many of those biological functions; nevertheless recent studies suggest functional roles for the glypican core proteins in mediating the signalling of various growth factors. READ MORE