Search for dissertations about: "N-methyl-D-aspartate"

Showing result 6 - 10 of 45 swedish dissertations containing the word N-methyl-D-aspartate.

  2. 6. Modeling and Mechanistic Investigation of α-synuclein aggregation

    Author : Alexander Svanbergsson; Neural plasticitet och reparation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Our understanding of the α-synuclein aggregation process and the consequences thereof is currently limited, which in turn prevents the development of targeted therapeutic interventions. The work presented here, as a part of this thesis, is focused on expanding our understanding of the molecular events involved in α-synuclein aggregation. READ MORE

  4. 7. Mechanisms of opiate tolerance and dependence in the rat

    Author : Orsolya Hoffman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Drug addiction is a complex phenomenon with various biological, psychological and social causes and consequences, which belongs to the major problems of today's society. Opiates have been used and misused for thousand of years and addiction to them develops both in humans and in animals. READ MORE

  5. 8. Growth hormone in the brain : Focus on cognitive function

    Author : Erika Brolin; Fred Nyberg; Mathias Hallberg; Alfhild Grönbladh; Jörgen Isgaard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; central nervous system; cognition; morphine; gamma-hydroxybutyrate; diabetes; Barnes maze; Morris water maze; mice; rats; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Cognitive impairments are an increasing health problem worldwide. In the developed countries, the average life expectancy has dramatically increased over the last decades, and with an elderly population more cases of cognitive impairments appear. READ MORE

  6. 9. Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena

    Author : Krzysztof Kucharz; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fragmentation; fission; endoplasmic reticulum; neurons; FRAP; primary cultures; organotypic slice cultures; in vivo; in situ; calcium; fusion; NMDA receptor; 2-photon microscopy; confocal microscopy;

    Abstract : The endoplasmic reticulum (ER) is crucial for protein synthesis and protein maturation, is involved in cell stress and serves in neurons as the major intracellular Ca2+ store. Neuronal ER forms a continuous network of cisterns and tubules extending from soma to a subset of dendritic spines. READ MORE

  7. 10. Brain immune mechanisms in schizophrenia : experimental and clinical characterization

    Author : Maximilian Tufvesson Alm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine pathway of tryptophan degradation, which produces an array of neuroactive metabolites. READ MORE