Search for dissertations about: "N-ras"

Found 3 swedish dissertations containing the word N-ras.

2. 1. Detection and analysis of genetic alterations in normal skin and skin tumours

   Author : Åsa Sivertsson; KTH; []
   Keywords : single cell; DNA sequencing; p53; mutation; UV; BCC; pyrosequencing; malignant melanoma; N-ras;

   Abstract : The investigation of genetic alterations in cancer-relatedgenes is useful for research, prognostic and therapeuticpurposes. However, the genetic heterogeneity that often occursduring tumour progression can make correct analysischallenging. READ MORE

4. 2. Malignant melanoma of the vulva

   Author : Boel Ragnarsson Olding; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Malignant melanoma; Vulvar melanoma; mucosal melanoma; epidemiology; amelanotic melanoma; pre-existing nevus; N-Ras mutation; TP53 mutation;

   Abstract : From a consecutive, nationwide series of 219 females with primary vulvar malignant melanomas diagnosed in Sweden during 1960 to 1984 and followed up until 1994, we analyzed epidemiological, clinical, histopathological, prognostic and molecular genetic data. The age-standardized incidence among these patients, 75 % of whom were 60 years old or more, decreased by 3. READ MORE

5. 3. Mutations and molecular signatures in human melanoma

   Author : Braslav Jovanovic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cutaneous melanoma is a disease which results from a complex mixture of various extrinsic and intrinsic factors, with some major players still unknown. Although primary tumors are highly curable with surgical excision, particularly those which are non-ulcerated and have a thickness of less than 1 mm, poor survival rates are observed in advanced disease. READ MORE