Search for dissertations about: "N-termini"

Showing result 1 - 5 of 16 swedish dissertations containing the word N-termini.

  2. 1. Rational modifications of cell-penetrating peptides for drug delivery : Applications in tumor targeting and oligonucleotide delivery

    Author : Maarja Mäe; Ülo Langel; Edvard Smith; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; oligonucleotide; drug delivery; tumor targeting; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : High molecular weight biomolecules are becoming important in the development of new therapeutics. However, their size and nature creates a major limitation for their application – poor penetration through biological membranes. READ MORE

  4. 2. Characterization of some molecules in the prophenoloxidase-activating and clotting systems in the freswater crayfish Pacifastacus leniusculus

    Author : Ruigong Wang; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologisk mykologi; Physiological Mycology;

    Abstract : A lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) was purified from crayfish hemocytes. LGBP has binding activity to lipopolysaccharide, curdlan (insoluble β-1,3-glucans) and laminarin (soluble β-1,3-glucans), but not to peptidoglycan. READ MORE

  5. 3. Structural and functional studies of nutrient and drug uptake systems

    Author : Fatma Guettou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Orally ingested nutrients and drugs are selectively absorbed from our small intestines into the bloodstream through various membrane-integrated transporters. The present study focuses mainly on a specific absorption route, namely the proton dependent oligopeptide transporters (POTs). READ MORE

  6. 4. New approaches for synthesis and analysis of adducts to N-terminal valine in hemoglobin from isocyanates, aldehydes, methyl vinyl ketone and diepoxybutane

    Author : Ronnie Davies; Margareta Törnqvist; Leif Kronberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbamoylation; modified-Edman procedure; 5- hydroxymethyl furfural; MISPE; biomarkers; Environmental chemistry; Miljökemi; miljökemi; Environmental Chemistry;

    Abstract : Human exposure to harmful compounds in the environment, from intake via food, occupational exposures or other sources, could have health implications. Exposure to reactive compounds/metabolites can be identified and quantified as hemoglobin (Hb) adducts by mass spectrometry. READ MORE

  7. 5. The Gene Repertoire of G protein-coupled Receptors : New Genes, Phylogeny, and Evolution

    Author : Þóra Kristín Bjarnadóttir; Helgi B. Schiöth; Robert Fredriksson; Kurt Kristiansen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Bioinformatics; Evolution; GPCR; Phylogeny; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. READ MORE