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Showing result 1 - 5 of 17 swedish dissertations matching the above criteria.

  2. 1. Characterization of the DNA-Binding Properties of the Cyanobacterial Transcription Factor NtcA

    Author : Susanne Wisén; Bengt Mannervik; Enrique Flores; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; NtcA; transcription regulation; cyanobacteria; redox regulation; DNA binding; nitrogen fixation; Anabaena PCC 7120; Biokemi; Biochemistry; Biokemi;

    Abstract : Nitrogen is an essential building block of proteins and nucleic acids and, therefore, crucial for the biosphere. Nearly 79 % of the air consists of nitrogen, but in the form of nitrogen gas (N2), which cannot be utilized by most organisms. READ MORE

  4. 2. A biophysical study of nucleic acid interactions with analogues and drugs

    Author : Ulrica Sehlstedt; Donald M Crothers; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nucleic acids; binding modes; polarised light spectroscopy; linear dichroism; NMR; triple helix; base-pair breathing dynamics; DAPI; porphyrins; quinoxaline derivatives; Biophysics; Biofysik; Biophysics; biofysik;

    Abstract : work presented in this thesis concerns studies on the physicochemical nature of interactions between nucleic acids and small ligands. The outcome of such studies can yield insights at a molecular level into the physiological mechanisms of action of biologically active nucleic-acid binding molecules. READ MORE

  5. 3. Substrate water binding to the oxygen-evolving complex in photosystem II

    Author : Håkan Nilsson; Johannes Messinger; Wolfgang Schröder; Robert L. Burnap; Umeå universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Photosynthesis; Photosystem II; water oxidation; oxygen evolution; substrate water exchange; membrane-inlet mass spectrometry;

    Abstract : Oxygenic photosynthesis in plants, algae and cyanobacteria converts sunlight into chemical energy. In this process electrons are transferred from water molecules to CO2 leading to the assembly of carbohydrates, the building blocks of life. READ MORE

  6. 4. Computational Studies of Nitrogenase

    Author : Lili Cao; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; nitrogenase; QM MM; quantum refinement; FeMo cluster; E4 state; N2 binding; V-nitrogenase; P-cluster; S2B dissociation; broken-symmetry state; homocitrate; DFT; protonation state; disorder; ComQumX-2QM;

    Abstract : AbstractNitrogenase is the only enzyme that can convert the inert nitrogen molecule to ammonia, so that it can be used for biomass production and in biosynthetic pathways. It contains a complicated acitve site, composed of eight metal ions, nine sulfur ions and one carbide ion (the FeMo cluster). READ MORE

  7. 5. Studies on oligonucleotide adducts formed from 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[A]pyrene stereoisomers

    Author : Ingrid Pontén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The widespread environmental pollutant benzo[a]pyrene (BP), is formed from incomplete combustion of fossil fuels and is mutagenic and carcinogenic after metabolic activation to bay-region diol epoxides and subsequent covalent binding to DNA. The metabolic activation pathway to diol epoxides is via BP-7,8-oxide and BP-7,8-dihydrodiol to yield preferentially 7R,8S-dihydroxy-9S,lOR-epoxy-7,8,9,10-tetrahydrobenzo[a]py- rene [(+)-anti-BPDE] and to lesser extents, 7R,8S-dihydroxy-9R,lOS-epoxy-BP [(-)-syn-BPDE], 7S,8R- dihydroxy-9S,lOR-epoxy-BP [(+)-syn-BPDE] and 7S,8R-dihydroxy-9R,lOS-epoxy-BP [(-)-anti-BPDE]. READ MORE