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Showing result 1 - 5 of 21 swedish dissertations matching the above criteria.

2. 1. CAR T cells for Immunotherapy of Cancer

   Author : Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

   Abstract : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. READ MORE

4. 2. Adenovirus for Cancer Therapy : With a Focus on its Surface Modification

   Author : Di Yu; Magnus Essand; Dirk Nettelbeck; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; cancer; therapy; neuroblastoma; neuroendocrine; modification; Tat; PTD; cell penetrating peptide; Helicobacter pylori; NAP; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Klinisk virologi; Clinical Virology; Medical Virology; Medicinsk virologi; Molekylär medicin; Molecular Medicine; Molekylär bioteknik; Molecular Biotechnology;

   Abstract : Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. However, its infectivity is highly dependent on the expression level of coxsackievirus-adenovirus receptor (CAR) on the surface of tumor cells. READ MORE

5. 3. Development of novel molecular methods for Campylobacter species and for Helicobacter pylori

   Author : Kristina Blom; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Campylobacter; Helicobacter pylori; PCR; mRNA; hybridization; flow cytometry; HpaA; urease; NAP;

   Abstract : Background and Aim: Different Campylobacter species and Helicobacter pylori are common causes of gastrointestinal infections that may result in diarrhea and chronic gastritis, respectively. The overall aim of this thesis was to develop novel methods for identification, differentiation and characterization of these bacteria. READ MORE

6. 4. Effects of trace elements in biodiesel on the performance of diesel oxidation catalysts in heavy-duty vehicles

   Author : Jonas Granestrand; Lars Pettersson; Todd J. Toops; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Diesel Oxidation catalyst; heavy-duty vehicles; catalyst deactivation; biodiesel; NAP-XPS; XANES; Phosphorus; alkali metals; Pt Pd Al2O3; Chemical Engineering; Kemiteknik;

   Abstract : To reduce net greenhouse gas emissions, a shift towards adoption of biofuels is ongoing in the transport sector. Heavy-duty diesel vehicles are equipped with aftertreatment equipment, comprising of catalysts and filters, and how this equipment is affected by the use of biofuels is not yet fully understood. READ MORE

7. 5. Cancer Immunotherapy : Oncolytic viruses and CAR-T cells

   Author : Jing Ma; Di Yu; Magnus Essand; Mia Phillipson; Mohanraj Ramachandran; Karl-Johan Malmberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; Oncolytic viruses; chimeric antigen receptor CAR -T cells; Helicobacter pylori Neutrophil Activating Protein;

   Abstract : Various forms of cancer immunotherapy have developed rapidly with improved survival and quality of life for cancer patients. Cancer immunotherapy aims to educate the patient’s immune system to eliminate cancer cells, including immune checkpoint inhibitors (ICIs), adoptive cell transfer (mostly T cells), oncolytic viruses (OVs) and cancer vaccines. READ MORE