Search for dissertations about: "NATURAL SCIENCES Biology Organism biology"
Showing result 1 - 5 of 190 swedish dissertations containing the words NATURAL SCIENCES Biology Organism biology.
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1. Systems Biology of Yeast Lipid Metabolism
Abstract : Lipid metabolism plays an important role in the development of many different life-style related diseases, such as type 2 diabetes and atherosclerosis, and understanding the molecular mechanisms behind regulation of lipid biosynthesis and degradation may lead to development of new therapies. In this project we undertook a global study of lipid metabolism in the eukaryotic model organism Saccharomyces cerevisiae. READ MORE
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2. Machine Learning Enabled Functional Discovery in Yeast Systems Biology
Abstract : Saccharomyces cerevisiae is a well-studied organism, yet roughly 20 percent of its proteins remain poorly characterized. Recent studies also seem to indicate that the pace of functional discovery is slow. READ MORE
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3. Transcriptional biomarkers of toxicity – powerful tools or random noise? : An applied perspective from studies on bivalves
Abstract : Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. READ MORE
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4. Surviving the ratchet : Modelling deleterious mutations in asexual populations
Abstract : One of the most unforgiving processes in nature is that of Muller's ratchet, a seemingly irreversible accumulation of deleterious mutations that all organisms have to deal with or face extinction. The most obvious way to avoid fitness collapse is recombination, though asexual populations usually do not have the luxury of recombining freely. READ MORE
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5. PARN - A Tale of A de-Tailor : Functional importance of poly(A) degradation in developmental and telomere biology disorders
Abstract : Poly(A)-specific ribonuclease (PARN) is a eukaryotic 3’-5’exoribonuclease that removes poly(A) tails of many coding and non-coding RNAs. In this thesis, we have studied the physiological role of PARN. READ MORE