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Showing result 1 - 5 of 51 swedish dissertations matching the above criteria.
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1. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State
Abstract : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. READ MORE
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2. Disarming bacteria : a structure-based approach to design an anti-virulence drug against Listeria monocytogenes
Abstract : Antibiotic resistances are one of the biggest threats to global health and if we don’t change our behavior and way of using antibiotics we will end up in a ‘post-antibiotic era’, in which common infections and minor injuries can once kill again and up to 10 million deaths per year may occur by 2050. Therefore, there is a high need for new anti-bacterial drugs, especially of alternatives to existing antibiotics with already described resistances. READ MORE
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3. Extracellular Matrix Based Materials for Tissue Engineering
Abstract : The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. READ MORE
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4. Thiopurine S-methyltransferase - characterization of variants and ligand binding
Abstract : Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. READ MORE
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5. Novel bioinspired and biohybrid electrode materials for hydrogen production
Abstract : This thesis was accomplished under the scope of eSCALED project administrated by EU MSCA horizon 2020 program, which aimed to develop a device called “artificial leaf” responsible for generating fuels or liquid chemicals (H2 production or CO2 reduction) using solar electrolysis. My objective was to develop a noble metal free, efficient cathode materials for H2 production for the device which yield this thesis. READ MORE